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- W2332514364 abstract "To the Editor: Colorectal cancer in young patients (age, 21 years or younger) is rare and has a well-recognized aggressive, often fatal course, but the genetic origin and developmental biology of this disease are poorly understood.1 We analyzed data from Memorial Sloan-Kettering Cancer Center on young patients with colorectal cancer to assess the hereditary basis of this disease. We used pedigree analysis and molecular assessment to identify microsatellite instability and other genetic markers. Microsatellite instability is a characteristic pattern of genetic instability seen in microsatellite DNA that occurs in most hereditary nonpolyposis colorectal cancers (more than 95 percent).2 Twenty-nine patients . . ." @default.
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- W2332514364 date "2000-01-13" @default.
- W2332514364 modified "2023-10-18" @default.
- W2332514364 title "Genetic and Phenotypic Correlates of Colorectal Cancer in Young Patients" @default.
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- W2332514364 doi "https://doi.org/10.1056/nejm200001133420216" @default.
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