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- W2332602105 abstract "The teratogenicity of disodium glycyrrhizinate (NaG) was examined in Wistar rats. Pregnant rats were fed diet containing 2%, 0.4% or 0.08% NaG ad libitum from day 0 to 20 of pregnancy. A comparison of the control and all groups of rats treated with NaG revealed no significant differences in food intake and in body weight gain during pregnancy. However, body weight gains after delivery were significantly lower in the two highest level groups. No significant differences between the control and NaG-treated groups were found in the numbers of corpora lutea and implants of dams, in the number of live fetuses and intrauterine dead fetuses per litter, in the sex ratios, in fetal body weight of both sexes, in the placental weight, in the degrees of ossification in the sternebrae and caudal vertebrae of the fetuses, or in the live birth index, survival rate or body weight gain of the offspring within 8 weeks after birth. Several kinds of skeletal variation of the fetus were observed in all the groups treated with NaG, but the incidences showed no significant differences as compared with the control. Except for one fetus with dilatation of the renal pelvis in the 0.08% group, no fetus with external, skeletal or internal malformations was found at any level examined. From these results, it can be concluded that NaG has no teratogenic effects on the fetus in rats." @default.
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- W2332602105 date "1985-01-01" @default.
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- W2332602105 title "Effect of Disodium Glycyrrhizinate on Pregnant Rats and Their Offspring" @default.
- W2332602105 doi "https://doi.org/10.3358/shokueishi.26.460" @default.
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