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• W2332635100 abstract "Event Abstract Back to Event Site specific delivery of cisplatin for improved cancer treatment Philip J. Reardon1*, Maryam Parhizkar2*, Richard J. Browning3*, Eleanor Stride3*, Mohan Edirisinghe2* and Jonathan C. Knowles1* 1 University College London, Division of Biomaterials and Tissue Engineering (Eastman Dental Institute), United Kingdom 2 University College London, Mechanical Engineering, United Kingdom 3 University of Oxford, Biomedical Engineering, United Kingdom Introduction: Platinum drugs such as cisplatin make up almost 50% of clinically used anticancer agents[1]. However their systemic use is associated with dose-limiting side effects and resistance. Therefore, designing a cisplatin drug carrier that can efficiently deliver drug at a given dosage in a site-specific manner is of great interest in cancer therapy. In this study, novel phosphate glass and nanosized polymeric cisplatin delivery systems of varying dosages have been prepared, and their applicability for cancer treatment assessed and compared based on diverse material characterisation. Experimental Methods: In vitro drug release measurements were carried out in PBS at 37°C, HPLC was used to determine the cisplatin concentration. Chromatographic conditions: mobile phase, methanol: 0.9% sodium chloride solution (95:5, V/V); flow rate: 0.7 ml/min, test wavelength 310 nm. Cisplatin loaded Sol-Gel Phosphate-based glass preparation was based upon the study by Foroutan et al[2]. Three different solutions with various Cisplatin to PLGA ratios (2.5, 5 and 10 wt% Cisplatin with respect to PLGA) were electro-sprayed using a single needle EHD setup to produce particles. Electrospraying parameters; flow rate of 5µl/min, voltage varied from 12 to 15 kV to form a stable cone jet. Material characterisation was performed using FTIR, XRD, FESEM, TEM and DSC. Results and Discussion: Figure 1 SEM micrographs of PLGA nanoparticles loaded with Cisplatin at (a) 2.5 wt%, (b) 5 wt%. Using a single-nozzle electrospraying setup, micro/nanoparticles containing different PLGA:drug ratios were synthesized with high encapsulation efficiency (>70%). Different particle dimensions were obtained by varying the cisplatin content, resulting in a mean particle size of ca. 1.60±0.20µm and 460±40nm for 5 and 2.5 wt% cisplatin respectively (Figure 1). Particle size was also manipulated by changing the ratio of the polymer/solvent mixture. Spherical nanomaterials with a mean particle size: ca. 290±40nm and containing 10 wt% cisplatin were obtained with a 2 wt% PLGA spraying solution. Polymeric and glass materials demonstrated a two-stage delivery profile, consisting of a faster release during 0-24 h followed by a slower more linear (first order) release period (Figure 2). Strong correlation of release profiles with the Higuchi model suggests that the release rate is diffusion controlled. Figure 2 Cisplatin delivery from PLGA nanomaterials and phosphate-based glass. The cisplatin release rate relative to the total loading amount was found to vary; the 5 wt% PLGA material released 15% more cisplatin relative to its payload than the 2.5 wt% loaded material after 8 h. Importantly, the quantity of cisplatin delivered from all materials over the release period correlated with the wt% of drug loading, demonstrating control of this parameter (Figure 2). Indicating these biomaterials could be promising candidates for drug delivery with controlled loading capacity and release period. Furthermore, based on the controllable production of cisplatin loaded nanomaterials, work on a targeted drug delivery system is underway. Conclusion: The findings highlight that novel electrospraying and sol-gel methodologies can be used to produce bioresorbable cisplatin drug delivery systems with controllable drug loading/delivery, which are of significance in developing appropriate materials suitable for drug delivery for cancer treatment. The authors would like to thank the EPSRC for providing financial support to this project.References:[1] Ma, P. a.; Xiao, H.; Li, C.; Dai, Y.; Cheng, Z.; Hou, Z.; Lin, J., Inorganic nanocarriers for platinum drug delivery. Materials Today.[2] Foroutan, F.; de Leeuw, N.; Martin, R.; Palmer, G.; Owens, G.; Kim, H.-W.; Knowles, J., Novel sol–gel preparation of (P2O5)0.4–(CaO)0.25–(Na2O)X–(TiO2)(0.35−X) bioresorbable glasses (X = 0.05, 0.1, and 0.15). J Sol-Gel Sci Technol 2015, 73 (2), 434-442. Keywords: Drug delivery, biomaterial, Polymeric material, Nano/micro particle Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials for therapeutic delivery Citation: Reardon PJ, Parhizkar M, Browning RJ, Stride E, Edirisinghe M and Knowles JC (2016). Site specific delivery of cisplatin for improved cancer treatment. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01671 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Philip J Reardon, University College London, Division of Biomaterials and Tissue Engineering (Eastman Dental Institute), London, United Kingdom, philip.reardon.09@ucl.ac.uk Dr. Maryam Parhizkar, University College London, Mechanical Engineering, London, United Kingdom, maryam.parhizkar.09@ucl.ac.uk Dr. Richard J Browning, University of Oxford, Biomedical Engineering, Oxford, United Kingdom, richard.browning@eng.ox.ac.uk Dr. Eleanor Stride, University of Oxford, Biomedical Engineering, Oxford, United Kingdom, eleanor.stride@eng.ox.ac.uk Dr. Mohan Edirisinghe, University College London, Mechanical Engineering, London, United Kingdom, m.edirisinghe@ucl.ac.uk Dr. Jonathan C Knowles, University College London, Division of Biomaterials and Tissue Engineering (Eastman Dental Institute), London, United Kingdom, j.knowles@ucl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Philip J Reardon Maryam Parhizkar Richard J Browning Eleanor Stride Mohan Edirisinghe Jonathan C Knowles Google Philip J Reardon Maryam Parhizkar Richard J Browning Eleanor Stride Mohan Edirisinghe Jonathan C Knowles Google Scholar Philip J Reardon Maryam Parhizkar Richard J Browning Eleanor Stride Mohan Edirisinghe Jonathan C Knowles PubMed Philip J Reardon Maryam Parhizkar Richard J Browning Eleanor Stride Mohan Edirisinghe Jonathan C Knowles Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2332635100 title "Site specific delivery of cisplatin for improved cancer treatment" @default.
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