Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332662340> ?p ?o ?g. }
- W2332662340 endingPage "10202" @default.
- W2332662340 startingPage "10194" @default.
- W2332662340 abstract "Killer whales in the NE Pacific Ocean are among the world’s most PCB-contaminated marine mammals, raising concerns about implications for their health. Sixteen health-related killer whale mRNA transcripts were analyzed in blubber biopsies collected from 35 free-ranging killer whales in British Columbia using real-time quantitative polymerase chain reaction. We observed PCB-related increases in the expression of five gene targets, including the aryl hydrocarbon receptor (AhR; r2 = 0.83; p < 0.001), thyroid hormone α receptor (TRα; r2 = 0.64; p < 0.001), estrogen α receptor (ERα; r2 = 0.70; p < 0.001), interleukin 10 (IL-10; r2 = 0.74 and 0.68, males and females, respectively; p < 0.001), and metallothionein 1 (MT1; r2 = 0.58; p < 0.001). Best-fit models indicated that population (dietary preference), age, and sex were not confounding factors, except for IL-10, where males differed from females. While the population-level consequences are unclear, the PCB-associated alterations in mRNA abundance of such pivotal end points provide compelling evidence of adverse physiological effects of persistent environmental contaminants in these endangered killer whales." @default.
- W2332662340 created "2016-06-24" @default.
- W2332662340 creator A5028374458 @default.
- W2332662340 creator A5033174273 @default.
- W2332662340 creator A5075119826 @default.
- W2332662340 creator A5082440634 @default.
- W2332662340 creator A5085013179 @default.
- W2332662340 creator A5085452882 @default.
- W2332662340 date "2011-11-02" @default.
- W2332662340 modified "2023-09-26" @default.
- W2332662340 title "PCB-Associated Changes in mRNA Expression in Killer Whales (<i>Orcinus orca</i>) from the NE Pacific Ocean" @default.
- W2332662340 cites W1583052686 @default.
- W2332662340 cites W1966110694 @default.
- W2332662340 cites W1977701885 @default.
- W2332662340 cites W1992784782 @default.
- W2332662340 cites W2001127044 @default.
- W2332662340 cites W2009900980 @default.
- W2332662340 cites W2015457320 @default.
- W2332662340 cites W2018386361 @default.
- W2332662340 cites W2018612452 @default.
- W2332662340 cites W2019007589 @default.
- W2332662340 cites W2019050518 @default.
- W2332662340 cites W2021874317 @default.
- W2332662340 cites W2023819857 @default.
- W2332662340 cites W2025894136 @default.
- W2332662340 cites W2029117563 @default.
- W2332662340 cites W2029539983 @default.
- W2332662340 cites W2032482174 @default.
- W2332662340 cites W2034555656 @default.
- W2332662340 cites W2034956231 @default.
- W2332662340 cites W2036413416 @default.
- W2332662340 cites W2046098761 @default.
- W2332662340 cites W2051342640 @default.
- W2332662340 cites W2053996154 @default.
- W2332662340 cites W2056862164 @default.
- W2332662340 cites W2058715647 @default.
- W2332662340 cites W2058902282 @default.
- W2332662340 cites W2070936807 @default.
- W2332662340 cites W2072679540 @default.
- W2332662340 cites W2073814069 @default.
- W2332662340 cites W2077220955 @default.
- W2332662340 cites W2079596704 @default.
- W2332662340 cites W2084355343 @default.
- W2332662340 cites W2085784849 @default.
- W2332662340 cites W2091657668 @default.
- W2332662340 cites W2093823326 @default.
- W2332662340 cites W2095278051 @default.
- W2332662340 cites W2099727427 @default.
- W2332662340 cites W2104284672 @default.
- W2332662340 cites W2107078518 @default.
- W2332662340 cites W2112274606 @default.
- W2332662340 cites W2126365517 @default.
- W2332662340 cites W2130725580 @default.
- W2332662340 cites W2133810375 @default.
- W2332662340 cites W2138317326 @default.
- W2332662340 cites W2141783094 @default.
- W2332662340 cites W2147458403 @default.
- W2332662340 cites W2148610258 @default.
- W2332662340 cites W2158232399 @default.
- W2332662340 cites W2158567075 @default.
- W2332662340 cites W2163941144 @default.
- W2332662340 cites W2165627850 @default.
- W2332662340 cites W2171867179 @default.
- W2332662340 cites W2171869842 @default.
- W2332662340 cites W2172777330 @default.
- W2332662340 cites W4210965306 @default.
- W2332662340 cites W4246051038 @default.
- W2332662340 cites W588606189 @default.
- W2332662340 doi "https://doi.org/10.1021/es201541j" @default.
- W2332662340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21985468" @default.
- W2332662340 hasPublicationYear "2011" @default.
- W2332662340 type Work @default.
- W2332662340 sameAs 2332662340 @default.
- W2332662340 citedByCount "75" @default.
- W2332662340 countsByYear W23326623402012 @default.
- W2332662340 countsByYear W23326623402013 @default.
- W2332662340 countsByYear W23326623402014 @default.
- W2332662340 countsByYear W23326623402015 @default.
- W2332662340 countsByYear W23326623402016 @default.
- W2332662340 countsByYear W23326623402017 @default.
- W2332662340 countsByYear W23326623402018 @default.
- W2332662340 countsByYear W23326623402019 @default.
- W2332662340 countsByYear W23326623402020 @default.
- W2332662340 countsByYear W23326623402021 @default.
- W2332662340 countsByYear W23326623402022 @default.
- W2332662340 countsByYear W23326623402023 @default.
- W2332662340 crossrefType "journal-article" @default.
- W2332662340 hasAuthorship W2332662340A5028374458 @default.
- W2332662340 hasAuthorship W2332662340A5033174273 @default.
- W2332662340 hasAuthorship W2332662340A5075119826 @default.
- W2332662340 hasAuthorship W2332662340A5082440634 @default.
- W2332662340 hasAuthorship W2332662340A5085013179 @default.
- W2332662340 hasAuthorship W2332662340A5085452882 @default.
- W2332662340 hasConcept C104317684 @default.
- W2332662340 hasConcept C121608353 @default.
- W2332662340 hasConcept C126322002 @default.
- W2332662340 hasConcept C134018914 @default.
- W2332662340 hasConcept C174455759 @default.