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- W2332666435 abstract "A series of novel ruthenium(II) complexes with electron-donor or electron-acceptor groups in intercalative ligands, [Ru(phen)2(o-MOPIP)]2+(1), [Ru(phen)2(o-MPIP)]2+(2), [Ru(phen)2(o-CPIP)]2+(3) and [Ru(phen)2(o-NPIP)]2+(4) have been synthesized and characterized with elementary, ES-MS, 1H NMR, electronic absorption and emission spectra. The binding properties of these complexes to CT-DNA have been investigated by spectroscopy and viscosity experiments. It’s illustrated that these complexes bind to DNA in a non-classical intercalation mode and their intrinsic binding constants (Kb) for 1, 2, 3 and 4 are calculated as 1.1, 0.35, 0.53 and 1.7 × 105 M-1, respectively. The Quantitative Structure-Activity Relationships (QSAR) of these ruthenium complexes, as well as some other ruthenium complexes congers has been investigated, and a linearity equation have been obtained: logKb=0.2429π+0.0429π2+0.2907σ+0.6 389I+4.3491 (n=12; R=0.9338; F=11.9134; p=0.0030). This results show that the electron-acceptor group and a large hydrophobic group will enhance the DNA binding affinity of ruthenium complexes." @default.
- W2332666435 created "2016-06-24" @default.
- W2332666435 creator A5049341927 @default.
- W2332666435 date "2016-01-01" @default.
- W2332666435 modified "2023-09-24" @default.
- W2332666435 title "Synthesis, DNA-binding Properties and Quantitative Structure-Activity Relationships on Ruthenium(II) Complexes with Calf-Thymus DNA" @default.
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- W2332666435 doi "https://doi.org/10.4172/2161-0444.1000338" @default.
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