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- W2332677977 startingPage "444" @default.
- W2332677977 abstract "肝保存時にCollins液(C)に加えてATP, allopurinol (AL), oxygen free radical scavengerであるsuperoxide dismutase (SOD)及びcatalase (CAT)等を単独であるいはこれを組み合わせて投与し,肝移植時に問題となるischemic及びreperfusion injuryの発症機序とその対策について肝潅流法を用いて検討した.ATPとALの併用群のみがcontrol群であるC群に比し,glucose産生,胆汁産生,肝のwet/dry weight, Na/K, energy chargeにおいて,有意の改善をみた.AL単独及びSOD/CATが無効であることよりhypothermic ischemic及びreperfusion injuryの発症においてoxygen free radicalは重要な役割を果たしていないことが示唆された.また,ATP併用によるALの有効性の機序はoxygen free radical産生防止によるものでなく,ATPの不可逆性の崩壊を防止することにより温存されたpurineがsalvage pathwayによりATPに再合成されるためと推察された." @default.
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- W2332677977 date "1989-01-01" @default.
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- W2332677977 title "The efficacy of ATP and allopurinol(AL) pretreatment against hypothermic ischemia-reperfusion injury of liver." @default.
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- W2332677977 doi "https://doi.org/10.2957/kanzo.30.444" @default.
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