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• W2332697216 endingPage "1191" @default.
• W2332697216 startingPage "1183" @default.
• W2332697216 abstract "Anti-benzo[a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide (anti-BPDE) is a known carcinogen that damages DNA, and this damage is influenced by the DNA sequence and epigenetic factors. The influence of epigenetic cytosine methylation on the reaction with anti-BPDE at a known hotspot DNA damage site was studied electrochemically. Gold electrodes were modified with thiolated DNA oligomers spanning codons 270–276 of the TP53 gene. The oligomers exhibited 5-carbon cytosine methylation at the codon 273 location on the bound probe, the acquired complementary target, or both. Redox active diviologen compounds of the form C12H25V2+C6H12V2+C12H25 (V2+ = 4,4′-bipyridyl or viologen, C12-Viologen) were employed to detect anti-BPDE damage to DNA. DNA was exposed to racemic (±)- or enantiomerically pure (+)-anti-BPDE solutions followed by electrochemical interrogation in the presence of C12-Viologen. Background subtracted square wave voltammograms (SWV) showed the appearance of two peaks at approximately −0.38 V and −0.55 V vs Ag/AgCl upon anti-BPDE exposure. The acquired voltammetry is consistent with singly reduced C12-Viologen dimers bound at two different DNA environments, which arise from BPDE damage and are influenced by cytosine methylation and BPDE stereochemical considerations. UV spectroscopic and mass spectrometric methods employed to validate the electrochemical responses showed that (+)-anti-BPDE primarily adopts a minor groove bound orientation within the oligomers while selectively targeting the nontranscribed ssDNA sequence within the duplexes." @default.
• W2332697216 created "2016-06-24" @default.
• W2332697216 creator A5002376573 @default.
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• W2332697216 date "2013-01-03" @default.
• W2332697216 modified "2023-10-16" @default.
• W2332697216 title "Electrochemical Study on the Effects of Epigenetic Cytosine Methylation on <i>Anti</i>-Benzo[<i>a</i>]pyrene Diol Epoxide Damage at TP53 Oligomers" @default.
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• W2332697216 doi "https://doi.org/10.1021/ac303077h" @default.
• W2332697216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23244159" @default.
• W2332697216 hasPublicationYear "2013" @default.
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