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- W2332719469 abstract "AFP産生胃癌の病理学的悪性度におけるmatrix metalloproteinases (MMPs)およびtissue inhibitor of metalloproteinases (TIMPs)の関与を解明するため, AFP産生胃癌(AFP-GC) 5例およびAFP非産生胃癌(Non AFP-GC) 48例におけるMMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2の免疫組織化学的発現性と病理学的因子を比較検討した. Non AFP-GCにおいて, MMP-2の発現率と脈管侵襲, MMP-7の発現率と腫瘍深達度・リンパ節転移に有意な関連が認められた.これらのMMPs, TIMPsの発現率は, AFP-GCとNon AFP-GCの間に差は認められなかった.胃癌の浸潤・転移過程においてMMP-2, MMP-7の関与が示唆されたが, AFP-GCの病理学的悪性度に関してMMP-2, MMP-7, MMP-9, TIMP-1, TIMP-2の関与は示唆されなかった." @default.
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- W2332719469 date "2003-01-01" @default.
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- W2332719469 title "A STUDY OF MMPs, TIMPs EXPRESSION AND PATHOLOGICAL MALIGNANT POTENTIAL IN GASTRIC CANCER DISTINGUISHED BY PRESENCE OF AFP PRODUCTION" @default.
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- W2332719469 doi "https://doi.org/10.3919/jjsa.64.1298" @default.
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