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- W2332743118 abstract "This paper describes a possibility that a metabolite of orally administered gefarnate (GF), an antiulcerative agent, is an acting substance, instead of GF.When GF was orally administered in rabbits or rats, its metabolites, farnesylacetic acid (FAA), geraniol etc. were clearly detected in portal or lymphatic flow, while mother compound GF was not detectable. FAA revealed about 100 times potent increase in the O2 consumption of mitochondria of rat liver than that of GF. When FAA (4 mg/kg) was intraperitoneally administered in rats, it showed a potent inhibitory effect on the stress ulcer, while oral administrations (1-260mg/ kg) were inactive or slightly adverse.These findings may be related to the assumption that FAA, a main metabolite, acts as a main pharmacologically active substance, but when it was directly applied to the surface of gastric mucosa with higher concentrations, it may inhibit the cellular respiration." @default.
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- W2332743118 date "1980-01-01" @default.
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- W2332743118 title "Studies on the Active Form of Oral Gefarnate" @default.
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- W2332743118 doi "https://doi.org/10.3999/jscpt.11.263" @default.
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