FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332743608> ?p ?o ?g. }

• W2332743608 endingPage "306" @default.
• W2332743608 startingPage "296" @default.
• W2332743608 abstract "Glucocorticoids (GC) often are administered during pregnancy, but despite their widespread use in clinical practice, it remains uncertain how GC exposure affects pro-angiogenic factors and their receptors. We investigated the effects of GC on vascular endothelial growth factor (VEGF), placental growth factor (PIGF), vascular endothelial growth factor receptor 1 (VEGFR1) and vascular endothelial growth factor receptor 2 (VEGFR2) protein and mRNA expressions and investigated the possible association of GC with the Akt/mTOR pathway. We incubated human umbilical vein endothelial cells (HUVECs) with a synthetic GC, triamcinolone acetonide (TA). TA administration caused decreased cellular and soluble VEGF and VEGFR1 protein expressions and increased soluble VEGFR2 expression. VEGF, VEGFR1 and VEGFR2 mRNA expressions were altered in a time and dose dependent manner. PIGF protein expression was unaffected by TA treatment, but PIGF mRNA expression decreased in a dose dependent manner after incubation for 48 and 72 h. Phospho-mTOR and phospho-Akt expressions were unaffected. Phospho-p70S6K and phospho-4EBP1 protein expressions and the vascular network forming capacity of HUVECs decreased in a dose dependent manner. We found that GC exert detrimental effects on angiogenesis by altering cellular and soluble angiogenic protein and mRNA levels, and vascular network forming capacities by the Akt/mTOR pathway." @default.
• W2332743608 created "2016-06-24" @default.
• W2332743608 creator A5005721556 @default.
• W2332743608 creator A5039795468 @default.
• W2332743608 creator A5053267497 @default.
• W2332743608 creator A5056621036 @default.
• W2332743608 creator A5060021270 @default.
• W2332743608 creator A5069178962 @default.
• W2332743608 creator A5076423641 @default.
• W2332743608 date "2016-03-23" @default.
• W2332743608 modified "2023-10-14" @default.
• W2332743608 title "Glucocorticoid effects on angiogenesis are associated with mTOR pathway activity" @default.
• W2332743608 cites W1495287184 @default.
• W2332743608 cites W1553291264 @default.
• W2332743608 cites W1582799478 @default.
• W2332743608 cites W1963849641 @default.
• W2332743608 cites W2002596243 @default.
• W2332743608 cites W2004372218 @default.
• W2332743608 cites W2012063336 @default.
• W2332743608 cites W2012700441 @default.
• W2332743608 cites W2014031706 @default.
• W2332743608 cites W2014087704 @default.
• W2332743608 cites W2016294374 @default.
• W2332743608 cites W2028939316 @default.
• W2332743608 cites W2037626596 @default.
• W2332743608 cites W2054296447 @default.
• W2332743608 cites W2063782675 @default.
• W2332743608 cites W2064770374 @default.
• W2332743608 cites W2067844754 @default.
• W2332743608 cites W2068754779 @default.
• W2332743608 cites W2079379519 @default.
• W2332743608 cites W2082731474 @default.
• W2332743608 cites W2093728377 @default.
• W2332743608 cites W2097881605 @default.
• W2332743608 cites W2109176791 @default.
• W2332743608 cites W2109812871 @default.
• W2332743608 cites W2120470778 @default.
• W2332743608 cites W2134473118 @default.
• W2332743608 cites W2137210420 @default.
• W2332743608 cites W2151178480 @default.
• W2332743608 cites W2154254227 @default.
• W2332743608 cites W2167549446 @default.
• W2332743608 cites W2169120384 @default.
• W2332743608 cites W2171331990 @default.
• W2332743608 cites W2172002215 @default.
• W2332743608 cites W4255042798 @default.
• W2332743608 doi "https://doi.org/10.3109/10520295.2016.1161234" @default.
• W2332743608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27007885" @default.
• W2332743608 hasPublicationYear "2016" @default.
• W2332743608 type Work @default.
• W2332743608 sameAs 2332743608 @default.
• W2332743608 citedByCount "10" @default.
• W2332743608 countsByYear W23327436082016 @default.
• W2332743608 countsByYear W23327436082017 @default.
• W2332743608 countsByYear W23327436082019 @default.
• W2332743608 countsByYear W23327436082020 @default.
• W2332743608 countsByYear W23327436082021 @default.
• W2332743608 countsByYear W23327436082023 @default.
• W2332743608 crossrefType "journal-article" @default.
• W2332743608 hasAuthorship W2332743608A5005721556 @default.
• W2332743608 hasAuthorship W2332743608A5039795468 @default.
• W2332743608 hasAuthorship W2332743608A5053267497 @default.
• W2332743608 hasAuthorship W2332743608A5056621036 @default.
• W2332743608 hasAuthorship W2332743608A5060021270 @default.
• W2332743608 hasAuthorship W2332743608A5069178962 @default.
• W2332743608 hasAuthorship W2332743608A5076423641 @default.
• W2332743608 hasConcept C126322002 @default.
• W2332743608 hasConcept C134018914 @default.
• W2332743608 hasConcept C146285616 @default.
• W2332743608 hasConcept C14858245 @default.
• W2332743608 hasConcept C167734588 @default.
• W2332743608 hasConcept C185592680 @default.
• W2332743608 hasConcept C202751555 @default.
• W2332743608 hasConcept C2776871010 @default.
• W2332743608 hasConcept C2777025900 @default.
• W2332743608 hasConcept C2777411675 @default.
• W2332743608 hasConcept C2780394083 @default.
• W2332743608 hasConcept C2780841215 @default.
• W2332743608 hasConcept C502942594 @default.
• W2332743608 hasConcept C55493867 @default.
• W2332743608 hasConcept C59493245 @default.
• W2332743608 hasConcept C62478195 @default.
• W2332743608 hasConcept C71924100 @default.
• W2332743608 hasConcept C75217442 @default.
• W2332743608 hasConcept C86554907 @default.
• W2332743608 hasConcept C86803240 @default.
• W2332743608 hasConcept C95444343 @default.
• W2332743608 hasConceptScore W2332743608C126322002 @default.
• W2332743608 hasConceptScore W2332743608C134018914 @default.
• W2332743608 hasConceptScore W2332743608C146285616 @default.
• W2332743608 hasConceptScore W2332743608C14858245 @default.
• W2332743608 hasConceptScore W2332743608C167734588 @default.
• W2332743608 hasConceptScore W2332743608C185592680 @default.
• W2332743608 hasConceptScore W2332743608C202751555 @default.
• W2332743608 hasConceptScore W2332743608C2776871010 @default.
• W2332743608 hasConceptScore W2332743608C2777025900 @default.
• W2332743608 hasConceptScore W2332743608C2777411675 @default.
• W2332743608 hasConceptScore W2332743608C2780394083 @default.

• next