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• W2332803836 abstract "Event Abstract Back to Event Stimuli-regulated cancer theranostics based on magnetic nanoparticles Yanglong Hou1 1 Peking University, College of Engineering, China Magnetic nanoparticles (NPs), which possess controlled size, shape and magnetic moments, have been applied as multifunctional probes in biomedical field, including MRI, drug delivery and magnetic hyperthermia, by enhancement of contrast in magnetic resonance imaging (MRI) and emote manipulation[1]. In this talk, we will first present general protol of monodisperse magnetic NPs, and then give an example of hollow manganese phosphate (HMP) NPs with particle size of 18 nm and a 10 nm hollow structure, for pH-modulated cancer cell targeted MRI and drug delivery[2]. Folic acid (FA) was selected as a target molecular for specific binding with cancer cells, and doxorubicin was loaded into the hollow structure for cancer therapy. This multifucntional probe can specifically target cancer cells overexpressing FA receptors, and be engulfed by lysosomes. The HMP NPs were dissolved at low pH environment in lysosomes, which can release Mn2+ for sensitive MRI, and DOX loaded for effective killing of cancer cells[3]. We then talk about Hagg iron carbide (Fe5C2) magnetic NPs for bimodal tumor imaging and therapy (Scheme)[4]-[6]. Interestingly, due to the presence of carbon layers of NPs, with high absorption in near-infrared (NIR) optical region, Fe5C2 NPs can be used for photoacoustic tomography (PAT) and photothermal therapy (PTT). The probe exhibits high saturation magnetization, r2 relaxivity and temperature increasing after exposure to NIR. The conjugation of Herceptin enabled the targeting to Her2-overexpressed cells (SK-OV-3 cells). After incubation with NPs in vitro, SK-OV-3 cells showed much lower MRI T2 signal, and no noticeable in vitro toxicity has been observed. Determined by using a fluorescent viability stain, cells incubated with NPs and exposed to NIR light were found to have undergone photothermally induced morbidity. The in vivo experiments were carried out on nude mice with ovarian cancer modal. After injection of NPs through the tail vein, it showed long-lasting negative-contrast enhancement MRI as well as high PAT signal at the tumor site. High tumore ablation was achieved after NIR irritation. From the loss of body weight, morphological and pathological examinations, almost no systematic toxicity has been observed. Our results highlight the great potential of Fe5C2 NPs as a multifunctional probe for cancer theranostic applications. This work was supported in part by National Natural Science Foundation of China (NSFC) (51125001, 51172005 and 81421004), the Research Fellowship for International Young Scientists of the National Natural Science Foundation of China (51450110437).References:[1] Hao R, Xing R & Hou Y∗, et al., Adv. Mater., 2010, 22, 2729-2742.[2] Hao R, Yu J & Hou Y∗, et al., Chem. Commun., 2011, 47, 9095-9097.[3] Yu J, Hao R & Hou Y∗, et al., Nano Res., 2012, 5, 679-694.[4] Yang C, Zhao & Hou Y∗, et al., J. Am. Chem. Soc., 2012, 134, 15814-15821.[5] Tang W, Zhen Z & Hou Y∗, et al., Small 2014, 7, 1245–1249.[6] Yu J, Yang C & Hou Y∗, et al, Adv. Mater., 2014, 26, 4114-4120. Keywords: nanoparticle, biofunctionalization, theranostic, targeting delivery Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: New Frontier Oral Topic: Cell-targeting biomaterials in theranostic delivery Citation: Hou Y (2016). Stimuli-regulated cancer theranostics based on magnetic nanoparticles. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01582 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Yanglong Hou Google Yanglong Hou Google Scholar Yanglong Hou PubMed Yanglong Hou Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2332803836 title "Stimuli-regulated cancer theranostics based on magnetic nanoparticles" @default.
• W2332803836 doi "https://doi.org/10.3389/conf.fbioe.2016.01.01582" @default.
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