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• W2332844488 abstract "PURPOSE/HYPOTHESIS: This study focused on cellular repair strategies (neural tissue transplantation) and exercise in the form of enriched environment (EE) on the recovery of complex forelimb functions in a rodent model of cervical spinal cord injury (SCI). The use of EE to promote growth of neurons in both the normal and injured brain is well established, however, it has received little attention with regard to SCI and potential interventions directed at functional repair. The objective was to test the effect of EE in combination with neural tissue transplantation on a battery of forelimb functions that provide a rigorous index of therapeutic efficacy. We hypothesized that recovery of forelimb function would be enhanced when coupled with EE compared to animals living in standard housing (SH). NUMBER OF SUBJECTS: Nine Sprague Dawley rats were included in this study. All animals received a C4 hemisection followed by a neural tissue transplantation (embryonic spinal cord tissue) 40 days post hemisection. MATERIALS/METHODS: Animals were randomly assigned to live in either an EE or SH for 90 days post transplantation. The EE was constructed of wire caging and contained running wheels, tubes, ladders, platforms, and an assortment of toys. All animals underwent behavioral testing prior to hemisection and then 10 days and 40 days after hemisection. Further testing occurred at 40 and 90 days post-transplant. Behavioral testing consisted of grip strength, runway walking, beam walking, and reaching. RESULTS: The EE group demonstrated significantly improved function compared with the SH group. In summary, by 90 post transplantation, significant differences were found in the grip strength (p = 0.05); runway (time to cross) (p= 0.04); and beam (time to cross) (p = 0.03) tasks. Marginal differences were seen in the reaching (p = 0.06) and runway walking (cadence) (p = 0.07) tasks. CONCLUSIONS: EE significantly enhanced functional outcomes after cervical hemisection/neural tissue transplantation in adult rats. These preliminary data justify further study on EE and programmed physical training paradigms and their use in combination with neural tissue transplantation. CLINICAL RELEVANCE: Transplantation of neural tissue into the human spinal cord is in its infancy. This study, however, suggests that once transplanted, the injured spinal cord must be actively engaged in motivationally driven behaviors in order to benefit from the effects of transplantation. If determined to be beneficial, these findings could lead to further study of human spinal cord transplantation with the addition of exercise in the form of enriched environment." @default.
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• W2332844488 date "2004-12-01" @default.
• W2332844488 modified "2023-09-26" @default.
• W2332844488 title "ENRICHED ENVIRONMENT AS AN ADJUNCT TO CELLULAR REPLACEMENT THERAPY FOR CHRONIC SPINAL CORD INJURY: PRELIMINARY FINDINGS." @default.
• W2332844488 doi "https://doi.org/10.1097/01253086-200412000-00032" @default.
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