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- W2332852080 abstract "Derivation of human embryonic stem cells (hESCs) from the in vitro fertilization (IVF) leftover embryos has brought a new era of cellular medicine for the heart [1-7]. The intrinsic ability of a hESC to both unlimited self-renew and differentiate into cardiac tissue elements makes it a practically inexhaustible source of replacement cells for the damaged heart. The hESC cardiac cell therapy derivatives are emerging as a new type of pharmacologic agent of cellular entity in cell-based regenerative medicine because they have direct pharmacologic utility and capacity for human myocardial tissue reconstitution and contractile function restoration that the conventional compound drug of molecular entity lacks [1-7]. Although a vast sum of government and private funding has been spent on looking for adult alternates, such as reprogramming and trans-differentiation of fibroblasts or mature tissues, so far, only human cardiac stem/precursor/ progenitor cells derived from embryo-originated hESCs have shown such cellular pharmacologic utility and capacity adequate for myocardium regeneration in pharmaceutical development of stem cell therapy for the damaged heart [1-7]." @default.
- W2332852080 created "2016-06-24" @default.
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- W2332852080 date "2013-01-01" @default.
- W2332852080 modified "2023-09-26" @default.
- W2332852080 title "The Designation of Human Cardiac Stem Cell Therapy Products for Human Trials" @default.
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- W2332852080 doi "https://doi.org/10.15226/2374-6882/1/1/00102" @default.
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