Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332852108> ?p ?o ?g. }
- W2332852108 endingPage "e1005967" @default.
- W2332852108 startingPage "e1005967" @default.
- W2332852108 abstract "The intricate shaping of the facial skeleton is essential for function of the vertebrate jaw and middle ear. While much has been learned about the signaling pathways and transcription factors that control facial patterning, the downstream cellular mechanisms dictating skeletal shapes have remained unclear. Here we present genetic evidence in zebrafish that three major signaling pathways - Jagged-Notch, Endothelin1 (Edn1), and Bmp - regulate the pattern of facial cartilage and bone formation by controlling the timing of cartilage differentiation along the dorsoventral axis of the pharyngeal arches. A genomic analysis of purified facial skeletal precursors in mutant and overexpression embryos revealed a core set of differentiation genes that were commonly repressed by Jagged-Notch and induced by Edn1. Further analysis of the pre-cartilage condensation gene barx1, as well as in vivo imaging of cartilage differentiation, revealed that cartilage forms first in regions of high Edn1 and low Jagged-Notch activity. Consistent with a role of Jagged-Notch signaling in restricting cartilage differentiation, loss of Notch pathway components resulted in expanded barx1 expression in the dorsal arches, with mutation of barx1 rescuing some aspects of dorsal skeletal patterning in jag1b mutants. We also identified prrx1a and prrx1b as negative Edn1 and positive Bmp targets that function in parallel to Jagged-Notch signaling to restrict the formation of dorsal barx1+ pre-cartilage condensations. Simultaneous loss of jag1b and prrx1a/b better rescued lower facial defects of edn1 mutants than loss of either pathway alone, showing that combined overactivation of Jagged-Notch and Bmp/Prrx1 pathways contribute to the absence of cartilage differentiation in the edn1 mutant lower face. These findings support a model in which Notch-mediated restriction of cartilage differentiation, particularly in the second pharyngeal arch, helps to establish a distinct skeletal pattern in the upper face." @default.
- W2332852108 created "2016-06-24" @default.
- W2332852108 creator A5010005812 @default.
- W2332852108 creator A5027333765 @default.
- W2332852108 creator A5035713110 @default.
- W2332852108 creator A5039908523 @default.
- W2332852108 creator A5059430063 @default.
- W2332852108 creator A5072940670 @default.
- W2332852108 creator A5075385072 @default.
- W2332852108 date "2016-04-08" @default.
- W2332852108 modified "2023-10-15" @default.
- W2332852108 title "Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face" @default.
- W2332852108 cites W1529528490 @default.
- W2332852108 cites W1547869018 @default.
- W2332852108 cites W1602845636 @default.
- W2332852108 cites W1878061663 @default.
- W2332852108 cites W1951644352 @default.
- W2332852108 cites W1951867641 @default.
- W2332852108 cites W1958621441 @default.
- W2332852108 cites W1963742875 @default.
- W2332852108 cites W1963834639 @default.
- W2332852108 cites W1969098700 @default.
- W2332852108 cites W1970985697 @default.
- W2332852108 cites W1972029559 @default.
- W2332852108 cites W1976781053 @default.
- W2332852108 cites W1979270809 @default.
- W2332852108 cites W1979395943 @default.
- W2332852108 cites W1980353886 @default.
- W2332852108 cites W1981242420 @default.
- W2332852108 cites W1987708524 @default.
- W2332852108 cites W1989920829 @default.
- W2332852108 cites W1990880194 @default.
- W2332852108 cites W1992289603 @default.
- W2332852108 cites W1993310108 @default.
- W2332852108 cites W1997441621 @default.
- W2332852108 cites W1998271982 @default.
- W2332852108 cites W1999526532 @default.
- W2332852108 cites W1999601285 @default.
- W2332852108 cites W2000060220 @default.
- W2332852108 cites W2001494846 @default.
- W2332852108 cites W2001589227 @default.
- W2332852108 cites W2005323886 @default.
- W2332852108 cites W2007215331 @default.
- W2332852108 cites W2008553597 @default.
- W2332852108 cites W2012708732 @default.
- W2332852108 cites W2012765331 @default.
- W2332852108 cites W2012864942 @default.
- W2332852108 cites W2016620270 @default.
- W2332852108 cites W2017224987 @default.
- W2332852108 cites W2017387566 @default.
- W2332852108 cites W2022906661 @default.
- W2332852108 cites W2023286906 @default.
- W2332852108 cites W2025589515 @default.
- W2332852108 cites W2028968420 @default.
- W2332852108 cites W2031111711 @default.
- W2332852108 cites W2031253393 @default.
- W2332852108 cites W2034493473 @default.
- W2332852108 cites W2035035873 @default.
- W2332852108 cites W2035245171 @default.
- W2332852108 cites W2036158219 @default.
- W2332852108 cites W2041232826 @default.
- W2332852108 cites W2045106437 @default.
- W2332852108 cites W2045315150 @default.
- W2332852108 cites W2049391874 @default.
- W2332852108 cites W2054486613 @default.
- W2332852108 cites W2054927713 @default.
- W2332852108 cites W2055669338 @default.
- W2332852108 cites W2055853433 @default.
- W2332852108 cites W2060181530 @default.
- W2332852108 cites W2070270500 @default.
- W2332852108 cites W2070403599 @default.
- W2332852108 cites W2076577834 @default.
- W2332852108 cites W2077515473 @default.
- W2332852108 cites W2079432590 @default.
- W2332852108 cites W2079772429 @default.
- W2332852108 cites W2082205112 @default.
- W2332852108 cites W2083517987 @default.
- W2332852108 cites W2084341282 @default.
- W2332852108 cites W2085483141 @default.
- W2332852108 cites W2086013207 @default.
- W2332852108 cites W2090164402 @default.
- W2332852108 cites W2091760375 @default.
- W2332852108 cites W2093260977 @default.
- W2332852108 cites W2094911771 @default.
- W2332852108 cites W2095313195 @default.
- W2332852108 cites W2096000660 @default.
- W2332852108 cites W2099230193 @default.
- W2332852108 cites W2100455164 @default.
- W2332852108 cites W2102806392 @default.
- W2332852108 cites W2103721311 @default.
- W2332852108 cites W2104784626 @default.
- W2332852108 cites W2108274213 @default.
- W2332852108 cites W2108754262 @default.
- W2332852108 cites W2109630666 @default.
- W2332852108 cites W2112121256 @default.
- W2332852108 cites W2112620431 @default.
- W2332852108 cites W2116461923 @default.
- W2332852108 cites W2117577488 @default.