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- W2332911779 abstract "Objective The objective of this article is to review the prospect of treating migraine with sphenopalatine ganglion (SPG) neurostimulation. Background Fuelled by preliminary studies showing a beneficial effect in cluster headache patients, the potential of treating migraine with neurostimulation has gained increasing interest within recent years, as current treatment strategies often fail to provide adequate relief from this debilitating headache. Common migraine symptoms include lacrimation, nasal congestion, and conjunctival injection, all parasympathetic manifestations. In addition, studies have suggested that parasympathetic activity may also contribute to the pain of migraineurs. The SPG is the largest extracranial parasympathetic ganglion of the head, innervating the meninges, lacrimal gland, nasal mucosa, and conjunctiva, all structures involved in migraine with cephalic autonomic symptoms. Conclusion We propose two possible mechanisms of action: 1) interrupting the post-ganglionic parasympathetic outflow to inhibit the pain and cephalic autonomic symptoms, and 2) modulating the sensory processing in the trigeminal nucleus caudalis. To further explore SPG stimulation in migraineurs as regards therapeutic potential and mode of action, randomized clinical trials are warranted." @default.
- W2332911779 created "2016-06-24" @default.
- W2332911779 creator A5013876563 @default.
- W2332911779 creator A5018653939 @default.
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- W2332911779 date "2013-11-29" @default.
- W2332911779 modified "2023-09-25" @default.
- W2332911779 title "Sphenopalatine ganglion neuromodulation in migraine: What is the rationale?" @default.
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- W2332911779 doi "https://doi.org/10.1177/0333102413512032" @default.
- W2332911779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24293088" @default.
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