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- W2332940919 abstract "Nephroblastoma overexpressed (NOV/CCN3), from the CCN gene family, is a secreted and matrix-associated protein, which is involved in many cellular functions such as growth, differentiation and adhesion. However, the effect of CCN3 in human prostate cancer is still unclear. Here, we found that CCN3 and intercellular adhesion molecule-1 (ICAM-1) expression level were related to cell migration ability in prostate cancer cells. In addition, CCN3 increased the migration and expression of ICAM-1 in human prostate cancer cells. RGD peptide, αvβ3 monoclonal antibody, integrin-linked kinase (ILK) and Akt inhibitors but not RAD peptide inhibited the CCN3-induced increase of the migration and ICAM-1 upregulation of prostate cancer cells. CCN3 stimulation activated the ILK/Akt/ NF-κB pathway. Moreover, CCN3 increased the binding of p65 to the NF-κB element on the ICAM-1 promoter. Finally, knock down of CCN3 expression markedly inhibited cell migration ability, tumor growth and bone destruction. Taken together, our results indicated that CCN3 enhances the migration of prostate cancer cells by increasing ICAM-1 expression through the αvβ3 integrin receptor/ ILK/ Akt and NF-κB signal transduction pathway. Therefore, CCN3 may be developed as alternate therapy of prostate cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1399. doi:10.1158/1538-7445.AM2011-1399" @default.
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- W2332940919 date "2011-04-15" @default.
- W2332940919 modified "2023-09-27" @default.
- W2332940919 title "Abstract 1399: CCN3 enhances migration and ICAM-1 upregulation via avb3 integrin, ILK, Akt, and NF-kB-dependent pathway in human prostate cancer cells" @default.
- W2332940919 doi "https://doi.org/10.1158/1538-7445.am2011-1399" @default.
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