FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332948078> ?p ?o ?g. }

• W2332948078 endingPage "155" @default.
• W2332948078 startingPage "131" @default.
• W2332948078 abstract "Abstract Animal models of Parkinson's disease (PD) are important for understanding the mechanisms of the disease and can contribute to developing and validating novel therapeutics. Ideally, these models should replicate the cardinal features of PD, such as progressive neurodegeneration of catecholaminergic neurons and motor defects. Many current PD models emphasize pathological forms of α-synuclein, based on findings that autosomal dominant mutations in α-synuclein and duplications/triplications of the SNCA gene cause PD. In addition, Lewy bodies and Lewy neurites, primarily composed of α-synuclein, represent the predominant pathological characteristics of PD. These inclusions have defined features, such as insolubility in non-ionic detergent, hyperphosphorylation, proteinase K sensitivity, a filamentous appearance by electron microscopy, and β-sheet structure. Furthermore, it has become clear that Lewy bodies and Lewy neurites are found throughout the peripheral and central nervous system, and could account not only for motor symptoms, but also for non-motor symptoms of the disease. The goal of this review is to describe two new α-synuclein-based models: the recombinant adeno-associated viral vector-α-synuclein model and the α-synuclein fibril model. An advantage of both models is that they do not require extensive crossbreeding of rodents transgenic for α-synuclein with other rodents transgenic for genes of interest to study the impact of such genes on PD-related pathology and phenotypes. In addition, abnormal α-synuclein can be expressed in brain regions relevant for disease. Here, we discuss the features of each model, how each model has contributed thus far to our understanding of PD, and the advantages and potential caveats of each model. This review describes two α-synuclein-based rodent models of Parkinson's disease: the rAAV-α-synuclein model and the α-synuclein fibril model. The key features of these models are described, and the extent to which they recapitulate features of PD, such as α-synuclein inclusion formation, loss of dopaminergic synapses in the striatum, motor defects, inflammation, and dopamine neuron death. This article is part of a special issue on Parkinson disease." @default.
• W2332948078 created "2016-06-24" @default.
• W2332948078 creator A5000374325 @default.
• W2332948078 creator A5013859812 @default.
• W2332948078 creator A5046016738 @default.
• W2332948078 creator A5049620072 @default.
• W2332948078 creator A5083016310 @default.
• W2332948078 date "2016-05-04" @default.
• W2332948078 modified "2023-10-10" @default.
• W2332948078 title "How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease?" @default.
• W2332948078 cites W1420421568 @default.
• W2332948078 cites W1480927111 @default.
• W2332948078 cites W1495464662 @default.
• W2332948078 cites W1496790952 @default.
• W2332948078 cites W1527671059 @default.
• W2332948078 cites W1544196343 @default.
• W2332948078 cites W154777429 @default.
• W2332948078 cites W1572679174 @default.
• W2332948078 cites W1642123135 @default.
• W2332948078 cites W1690318953 @default.
• W2332948078 cites W1767392319 @default.
• W2332948078 cites W1785605997 @default.
• W2332948078 cites W1811548175 @default.
• W2332948078 cites W1845531777 @default.
• W2332948078 cites W1856731619 @default.
• W2332948078 cites W1877873625 @default.
• W2332948078 cites W1886318170 @default.
• W2332948078 cites W1951215936 @default.
• W2332948078 cites W1957569525 @default.
• W2332948078 cites W1965095016 @default.
• W2332948078 cites W1965624208 @default.
• W2332948078 cites W1966598943 @default.
• W2332948078 cites W1972715091 @default.
• W2332948078 cites W1972931472 @default.
• W2332948078 cites W1973738022 @default.
• W2332948078 cites W1978793506 @default.
• W2332948078 cites W1979659124 @default.
• W2332948078 cites W1980342220 @default.
• W2332948078 cites W1981619752 @default.
• W2332948078 cites W1985287196 @default.
• W2332948078 cites W1988364986 @default.
• W2332948078 cites W1989734945 @default.
• W2332948078 cites W1989913002 @default.
• W2332948078 cites W1997417422 @default.
• W2332948078 cites W1998207492 @default.
• W2332948078 cites W2003181166 @default.
• W2332948078 cites W2006157687 @default.
• W2332948078 cites W2006622455 @default.
• W2332948078 cites W2008704732 @default.
• W2332948078 cites W2015784694 @default.
• W2332948078 cites W2018907079 @default.
• W2332948078 cites W2022245282 @default.
• W2332948078 cites W2024356065 @default.
• W2332948078 cites W2025810715 @default.
• W2332948078 cites W2026455995 @default.
• W2332948078 cites W2028649842 @default.
• W2332948078 cites W2036643788 @default.
• W2332948078 cites W2044051356 @default.
• W2332948078 cites W2044908785 @default.
• W2332948078 cites W2045244036 @default.
• W2332948078 cites W2047565527 @default.
• W2332948078 cites W2050786534 @default.
• W2332948078 cites W2053206193 @default.
• W2332948078 cites W2054281736 @default.
• W2332948078 cites W2056022228 @default.
• W2332948078 cites W2056675110 @default.
• W2332948078 cites W2061995199 @default.
• W2332948078 cites W2063202995 @default.
• W2332948078 cites W207007096 @default.
• W2332948078 cites W2073449985 @default.
• W2332948078 cites W2074436622 @default.
• W2332948078 cites W2075793841 @default.
• W2332948078 cites W2084334114 @default.
• W2332948078 cites W2086117912 @default.
• W2332948078 cites W2086738605 @default.
• W2332948078 cites W2089607910 @default.
• W2332948078 cites W2090946801 @default.
• W2332948078 cites W2091265794 @default.
• W2332948078 cites W2100894616 @default.
• W2332948078 cites W2100898704 @default.
• W2332948078 cites W2101167927 @default.
• W2332948078 cites W2102302018 @default.
• W2332948078 cites W2103623402 @default.
• W2332948078 cites W2104281624 @default.
• W2332948078 cites W2108705280 @default.
• W2332948078 cites W2111216320 @default.
• W2332948078 cites W2115298392 @default.
• W2332948078 cites W2118696695 @default.
• W2332948078 cites W2120001716 @default.
• W2332948078 cites W2123403456 @default.
• W2332948078 cites W2123431154 @default.
• W2332948078 cites W2128497706 @default.
• W2332948078 cites W2133962007 @default.
• W2332948078 cites W2141459724 @default.
• W2332948078 cites W2143515674 @default.
• W2332948078 cites W2143604504 @default.
• W2332948078 cites W2145294211 @default.
• W2332948078 cites W2148214085 @default.

• next