Matches in SemOpenAlex for { <https://semopenalex.org/work/W2332983256> ?p ?o ?g. }
- W2332983256 endingPage "3047" @default.
- W2332983256 startingPage "3047" @default.
- W2332983256 abstract "Purpose.: We explored the relationship between the renin-angiotensin system (RAS) and aquaporins (AQP1 and AQP4 in Müller glia and astrocytes) in diabetic retinopathy (DR) with and without systemic hypertension. Methods.: Diabetes was induced in spontaneously hypertensive rats (SHR) and normotensive control Wistar Kyoto (WKY) rats by intraperitoneal injections of streptozotocin. The diabetic and control non-diabetic rats were assigned randomly to receive no anti-hypertension treatment, or to be treated with the angiotensin II receptor blocker (ARB), valsartan (40 mg/kg/d) or the beta-blocker, metoprolol (50 mg/kg/day). Eight weeks later, retinas were evaluated by immunohistochemistry and Western blot to detect changes in the expression of AQP1, AQP4, and glial fibrillary acidic protein (GFAP). Results.: Hypertension increased expression of glial GFAP and AQP4 (P < 0.01), but not AQP1 (P > 0.05) in diabetic rats. Valsartan and metoprolol decreased GFAP, AQP1, and AQP4 expression in diabetic SHR rats (P < 0.01). Valsartan decreased GFAP and AQP1 expression in diabetic WKY rats (P < 0.01), while metoprolol did not. Conclusions.: Activation of Müller glia and astrocytes was involved in the mechanism by which systemic hypertension affects DR. AQPs and macroglia were linked to changes in the RAS in DR. Changes in aquaporin expression in DR were increased by hypertension. This provides additional support for the early use of an ARB in the treatment of DR, especially in cases with retinal edema." @default.
- W2332983256 created "2016-06-24" @default.
- W2332983256 creator A5014997177 @default.
- W2332983256 creator A5018217357 @default.
- W2332983256 creator A5040583635 @default.
- W2332983256 creator A5041604269 @default.
- W2332983256 creator A5067167485 @default.
- W2332983256 creator A5074140059 @default.
- W2332983256 date "2012-05-17" @default.
- W2332983256 modified "2023-10-18" @default.
- W2332983256 title "Aquaporin Changes during Diabetic Retinopathy in Rats Are Accelerated by Systemic Hypertension and Are Linked to the Renin-Angiotensin System" @default.
- W2332983256 cites W1495656315 @default.
- W2332983256 cites W1578613579 @default.
- W2332983256 cites W1973221286 @default.
- W2332983256 cites W1986997164 @default.
- W2332983256 cites W1990030817 @default.
- W2332983256 cites W1991147219 @default.
- W2332983256 cites W1993762245 @default.
- W2332983256 cites W1996535827 @default.
- W2332983256 cites W1996922044 @default.
- W2332983256 cites W2000228087 @default.
- W2332983256 cites W2000352038 @default.
- W2332983256 cites W2013459762 @default.
- W2332983256 cites W2020118541 @default.
- W2332983256 cites W202302843 @default.
- W2332983256 cites W2029328871 @default.
- W2332983256 cites W2031099464 @default.
- W2332983256 cites W2035617981 @default.
- W2332983256 cites W2050060206 @default.
- W2332983256 cites W2056038262 @default.
- W2332983256 cites W2060207361 @default.
- W2332983256 cites W2066840018 @default.
- W2332983256 cites W2069098382 @default.
- W2332983256 cites W2069594832 @default.
- W2332983256 cites W2084223745 @default.
- W2332983256 cites W2087566026 @default.
- W2332983256 cites W2089325709 @default.
- W2332983256 cites W2089450477 @default.
- W2332983256 cites W2095638157 @default.
- W2332983256 cites W2098428548 @default.
- W2332983256 cites W2109689720 @default.
- W2332983256 cites W2118871716 @default.
- W2332983256 cites W2120294503 @default.
- W2332983256 cites W2120723151 @default.
- W2332983256 cites W2133695167 @default.
- W2332983256 cites W2149471545 @default.
- W2332983256 cites W2162837978 @default.
- W2332983256 cites W2166110343 @default.
- W2332983256 cites W2166836178 @default.
- W2332983256 cites W22189248 @default.
- W2332983256 cites W3134431802 @default.
- W2332983256 cites W3198570063 @default.
- W2332983256 cites W2044914889 @default.
- W2332983256 cites W2520201354 @default.
- W2332983256 doi "https://doi.org/10.1167/iovs.11-9154" @default.
- W2332983256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22491408" @default.
- W2332983256 hasPublicationYear "2012" @default.
- W2332983256 type Work @default.
- W2332983256 sameAs 2332983256 @default.
- W2332983256 citedByCount "17" @default.
- W2332983256 countsByYear W23329832562014 @default.
- W2332983256 countsByYear W23329832562015 @default.
- W2332983256 countsByYear W23329832562016 @default.
- W2332983256 countsByYear W23329832562017 @default.
- W2332983256 countsByYear W23329832562019 @default.
- W2332983256 countsByYear W23329832562020 @default.
- W2332983256 countsByYear W23329832562022 @default.
- W2332983256 countsByYear W23329832562023 @default.
- W2332983256 crossrefType "journal-article" @default.
- W2332983256 hasAuthorship W2332983256A5014997177 @default.
- W2332983256 hasAuthorship W2332983256A5018217357 @default.
- W2332983256 hasAuthorship W2332983256A5040583635 @default.
- W2332983256 hasAuthorship W2332983256A5041604269 @default.
- W2332983256 hasAuthorship W2332983256A5067167485 @default.
- W2332983256 hasAuthorship W2332983256A5074140059 @default.
- W2332983256 hasBestOaLocation W23329832561 @default.
- W2332983256 hasConcept C126322002 @default.
- W2332983256 hasConcept C127413603 @default.
- W2332983256 hasConcept C134018914 @default.
- W2332983256 hasConcept C170493617 @default.
- W2332983256 hasConcept C198710026 @default.
- W2332983256 hasConcept C201289731 @default.
- W2332983256 hasConcept C204232928 @default.
- W2332983256 hasConcept C2775845273 @default.
- W2332983256 hasConcept C2777387769 @default.
- W2332983256 hasConcept C2779280383 @default.
- W2332983256 hasConcept C2779716603 @default.
- W2332983256 hasConcept C2779829184 @default.
- W2332983256 hasConcept C2780495277 @default.
- W2332983256 hasConcept C2908929049 @default.
- W2332983256 hasConcept C555293320 @default.
- W2332983256 hasConcept C71924100 @default.
- W2332983256 hasConcept C78519656 @default.
- W2332983256 hasConcept C84393581 @default.
- W2332983256 hasConcept C85562759 @default.
- W2332983256 hasConceptScore W2332983256C126322002 @default.
- W2332983256 hasConceptScore W2332983256C127413603 @default.
- W2332983256 hasConceptScore W2332983256C134018914 @default.