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- W2333007416 abstract "<h3>Background</h3> Infection and inflammation can be antecedents of Neonatal Encephalopathy (NE) and increase the risk of neurological sequelae. Vitamin D is a potent immunomodulator and may alter the systemic inflammatory repose in NE. <h3>Aim</h3> To investigate the <i><i>in vitro</i></i> effect of 1,25(OH)<sub>2</sub>D<sub>3 </sub>on whole blood intracellular neutrophil production of ROI in NE patients at 72–96 h of age. <h3>Methods</h3> Infants with NE were recruited and their demographics details, grade of NE, MRI results, outcome and placental histology were recorded. Whole blood was taken between 72 -96 h of age and analysed using flow cytometry for Toll-like Receptor (TLR)4, CD11b and reactive oxygen intermediates (ROI) in both monocytes and neutrophils in the presence of Lipopolysaccharide (LPS) and/or 1,25(OH)<sub>2</sub>D<sub>3</sub>. <h3>Results</h3> Five neonates with NE were recruited and all received therapeutic hypothermia (TH). At 72–96 h of age following TH there was enhanced production of monocyte and neutrophil ROI in the presence of LPS and this was augmented by 1,25(OH)<sub>2</sub>D<sub>3 </sub>pretreatment<i>in vitro</i>. Similar effects were seen on TLR4 and CD11b production in both neutrophils and monocytes. <h3>Conclusion</h3> 1,25(OH)<sub>2</sub>D<sub>3 </sub>increases the productionof ROI in neutrophils and which may not be beneficial in NE in which an augmented systemic inflammation is underway." @default.
- W2333007416 created "2016-06-24" @default.
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- W2333007416 date "2014-10-01" @default.
- W2333007416 modified "2023-09-27" @default.
- W2333007416 title "PO-0440 Vitamin D Increases Immune Responses In Neonatal Encephalopathyin Vitro" @default.
- W2333007416 doi "https://doi.org/10.1136/archdischild-2014-307384.1082" @default.
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