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- W2333020137 abstract "Two series of iododiflunisal and diflunisal analogues have been obtained by using a two step sequential reaction solution-phase parallel synthesis. The synthesis combined an aqueous Suzuki-Miyaura cross-coupling and a mild electrophilic aromatic iodination step using a new polymer-supported iodonium version of Barluenga’s reagent. From a selected set of 77 noniodinated and 77 iodinated diflunisal analogues, a subset of good transthyretin amyloid inhibitors has been obtained with improved turbidimetry inhibition constants, high binding affinity to transthyretin, and good selectivity for TTR compared to other thyroxine binding proteins." @default.
- W2333020137 created "2016-06-24" @default.
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- W2333020137 date "2014-11-25" @default.
- W2333020137 modified "2023-10-17" @default.
- W2333020137 title "Tuning Transthyretin Amyloidosis Inhibition Properties of Iododiflunisal by Combinatorial Engineering of the Nonsalicylic Ring Substitutions" @default.
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- W2333020137 doi "https://doi.org/10.1021/co5001234" @default.
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