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- W2333023489 abstract "Summary and ConclusionsPregneninolone, though chemically very closely related to both testosterone and progesterone, does not manifest in women the same multiplicity of biological properties that it does in experimental animals. In women, its most striking property is its progestomimetic effect on the estrogen-primed endo-metrium, when administered orally.In contrast to its action in rats, in women pregneninolone appears to have: (a) no estromimetic effect on the endometrium and only a very slight effect on the vaginal epithelium if given in very large doses; and (b) no arrhenomimetic effects.Two interesting observations emerge from this study that are worthy of note. First, the profound change in biologic activity that resulted from the introduction of the ethinyl group at the 17th carbon atom of the testosterone molecule, which is the only manner in which pregneninolone differs from testosterone. Second, the striking difference in the biological properties displayed by the same compound when administere..." @default.
- W2333023489 created "2016-06-24" @default.
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- W2333023489 date "1940-11-01" @default.
- W2333023489 modified "2023-09-27" @default.
- W2333023489 title "Biological Properties of Pregneninolone (17-Ethinyl Testosterone) in Women" @default.
- W2333023489 doi "https://doi.org/10.3181/00379727-45-11738p" @default.
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