FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333033610> ?p ?o ?g. }

• W2333033610 endingPage "1141" @default.
• W2333033610 startingPage "1135" @default.
• W2333033610 abstract "Activating Transcription Factor 3 (ATF3) is a member of the bZip family of transcription factors. Previous studies in mammalian cells suggested that like other bZip family members e.g. Jun and Fos, ATF3 might play a role in the control of cell proliferation and participate in oncogenic transformation. To investigate this putative ATF3 function directly, the rat ATF3 protein was compared with v-Jun for its ability to transform primary cultures of chick embryo fibroblasts (CEFs). Like CEFs accumulating v-Jun, CEFs accumulating the ATF3 protein displayed a typical, fusiform morphology, associated with an enhanced capacity to grow in medium with reduced amount of serum. However, in contrast to v-Jun-transformed CEFs, the ATF3 overexpressing cells could not promote colony formation from single cells in agar. Partial transformation induced by ATF3 was found to be associated with repression of multiple cellular genes that are also down-regulated by v-Jun, including those coding for the extracellular components fibronectin, decorin, thrombospondin 2, and the pro-apoptotic protein Par-4. These data demonstrate that, at least in primary avian cells, rat ATF3 possesses an intrinsic oncogenic potential. Moreover, the results suggest that ATF3 might induce growth factor independence by down-regulating a subset of the genes repressed by v-Jun." @default.
• W2333033610 created "2016-06-24" @default.
• W2333033610 creator A5005618621 @default.
• W2333033610 creator A5015796005 @default.
• W2333033610 creator A5038494400 @default.
• W2333033610 creator A5062282123 @default.
• W2333033610 date "2001-03-01" @default.
• W2333033610 modified "2023-10-10" @default.
• W2333033610 title "Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation" @default.
• W2333033610 cites W1489145497 @default.
• W2333033610 cites W1513067957 @default.
• W2333033610 cites W1545398558 @default.
• W2333033610 cites W1798443799 @default.
• W2333033610 cites W1869555064 @default.
• W2333033610 cites W1927565545 @default.
• W2333033610 cites W1969181305 @default.
• W2333033610 cites W1969281472 @default.
• W2333033610 cites W1987453246 @default.
• W2333033610 cites W1998130451 @default.
• W2333033610 cites W2016929854 @default.
• W2333033610 cites W2023666553 @default.
• W2333033610 cites W2027116827 @default.
• W2333033610 cites W2036129260 @default.
• W2333033610 cites W2036224418 @default.
• W2333033610 cites W2056729019 @default.
• W2333033610 cites W2064265900 @default.
• W2333033610 cites W2067837253 @default.
• W2333033610 cites W2075556833 @default.
• W2333033610 cites W2076198744 @default.
• W2333033610 cites W2077567193 @default.
• W2333033610 cites W2079520714 @default.
• W2333033610 cites W2082688528 @default.
• W2333033610 cites W2085967407 @default.
• W2333033610 cites W2086186491 @default.
• W2333033610 cites W2098132781 @default.
• W2333033610 cites W2109399660 @default.
• W2333033610 cites W2116197923 @default.
• W2333033610 cites W2117798803 @default.
• W2333033610 cites W2119579682 @default.
• W2333033610 cites W2120955132 @default.
• W2333033610 cites W2141897480 @default.
• W2333033610 cites W2144517045 @default.
• W2333033610 cites W2160767270 @default.
• W2333033610 cites W2162644348 @default.
• W2333033610 cites W2198974858 @default.
• W2333033610 cites W2322768926 @default.
• W2333033610 cites W2324347911 @default.
• W2333033610 cites W2329930272 @default.
• W2333033610 cites W2333540356 @default.
• W2333033610 cites W4230431755 @default.
• W2333033610 doi "https://doi.org/10.1038/sj.onc.1204200" @default.
• W2333033610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11314051" @default.
• W2333033610 hasPublicationYear "2001" @default.
• W2333033610 type Work @default.
• W2333033610 sameAs 2333033610 @default.
• W2333033610 citedByCount "58" @default.
• W2333033610 countsByYear W23330336102012 @default.
• W2333033610 countsByYear W23330336102013 @default.
• W2333033610 countsByYear W23330336102014 @default.
• W2333033610 countsByYear W23330336102016 @default.
• W2333033610 countsByYear W23330336102020 @default.
• W2333033610 countsByYear W23330336102021 @default.
• W2333033610 countsByYear W23330336102022 @default.
• W2333033610 countsByYear W23330336102023 @default.
• W2333033610 crossrefType "journal-article" @default.
• W2333033610 hasAuthorship W2333033610A5005618621 @default.
• W2333033610 hasAuthorship W2333033610A5015796005 @default.
• W2333033610 hasAuthorship W2333033610A5038494400 @default.
• W2333033610 hasAuthorship W2333033610A5062282123 @default.
• W2333033610 hasBestOaLocation W23330336101 @default.
• W2333033610 hasConcept C101762097 @default.
• W2333033610 hasConcept C104317684 @default.
• W2333033610 hasConcept C150194340 @default.
• W2333033610 hasConcept C157880135 @default.
• W2333033610 hasConcept C170493617 @default.
• W2333033610 hasConcept C2775960820 @default.
• W2333033610 hasConcept C2778753947 @default.
• W2333033610 hasConcept C2780631158 @default.
• W2333033610 hasConcept C54355233 @default.
• W2333033610 hasConcept C62112901 @default.
• W2333033610 hasConcept C77179829 @default.
• W2333033610 hasConcept C86339819 @default.
• W2333033610 hasConcept C86803240 @default.
• W2333033610 hasConcept C95444343 @default.
• W2333033610 hasConceptScore W2333033610C101762097 @default.
• W2333033610 hasConceptScore W2333033610C104317684 @default.
• W2333033610 hasConceptScore W2333033610C150194340 @default.
• W2333033610 hasConceptScore W2333033610C157880135 @default.
• W2333033610 hasConceptScore W2333033610C170493617 @default.
• W2333033610 hasConceptScore W2333033610C2775960820 @default.
• W2333033610 hasConceptScore W2333033610C2778753947 @default.
• W2333033610 hasConceptScore W2333033610C2780631158 @default.
• W2333033610 hasConceptScore W2333033610C54355233 @default.
• W2333033610 hasConceptScore W2333033610C62112901 @default.
• W2333033610 hasConceptScore W2333033610C77179829 @default.
• W2333033610 hasConceptScore W2333033610C86339819 @default.
• W2333033610 hasConceptScore W2333033610C86803240 @default.
• W2333033610 hasConceptScore W2333033610C95444343 @default.

• next