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- W2333095129 abstract "Quantitative influence of non-hormonal blood factors on the control of sodium excretion by the isolated dog kidney.On the basis of experiments performed on isolated dog kidneys, thus eliminating extrarenal hormonal controls, an attempt has been made to evaluate the influence of arterial blood pressure and several non-hormonal blood parameters on fractional sodium excretion.The roles of plasma protein concentration as modulated by filtration fraction, total renal plasma flow, hematocrit, arterial pressure and plasma potassium concentration on overall fractional sodium reabsorption have been evidenced and quantitatively evaluated.Although the control of sodium reabsorption by renal plasma flow and by hematocrit can be ascribed partly to changes in filtration fraction and post-glomerular plasma protein concentration, other mechanisms appear to be involved as well.Variations in filtration fraction and postglomerular plasma protein concentration play little, if any, role in the induction of pressure natriuresis.The autonomous and quantitative response of the kidney to blood dilution during saline diuresis represents the cumulative results, not only of the dilution of pre- and postglomerular plasma proteins, but also of the simultaneous decrease of hematocrit and increase of renal plasma flow.The implications of these results for the understanding of the adjustment of sodium balance in acute and chronic conditions are discussed." @default.
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- W2333095129 date "1972-01-01" @default.
- W2333095129 modified "2023-09-26" @default.
- W2333095129 title "Quantitative influence of non-hormonal blood factors on the control of sodium excretion by the isolated dog kidney" @default.
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- W2333095129 doi "https://doi.org/10.1038/ki.1972.5" @default.
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