FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333151971> ?p ?o ?g. }

• W2333151971 endingPage "1258" @default.
• W2333151971 startingPage "1244" @default.
• W2333151971 abstract "The ability of a single protein fold to make multi-modal interactions with itself and others for transmitting biological signals across multiple receptor families is a recurring theme in signal transduction. The Toll/IL-1 receptor (TIR) domain represents an evolutionarily conserved alpha-beta Flavodoxin-like protein fold [1], which has evolved complex multifaceted molecular interactions capable of transmitting a variety of developmental and immunological signals. In mammals, TIR domains are found on both interleukin-1 receptors (IL-1Rs) and Toll-like receptors (TLRs), as well as in cytoplasmic signaling adaptors and endogenous regulatory proteins. Appropriate TIR-TIR mediated immune interactions result in cytokine responses, pathogen clearance and host immune protection, while inappropriate signaling can lead to autoimmunity, inflammation and death. In the past decade, a number of three-dimensional structures of individual TIR domains have been elucidated. When coupled with the wealth of information from mutagenesis, genetic and peptide studies, this structural data provides additional insight to the molecular mechanisms underlying signal transduction mediated by interactions between TIR domains. Owing to their ability to regulate both innate and adaptive immune responses in a variety of organisms including humans, TIR domain-mediated molecular interactions are of intense interest for therapies targeting autoimmunity, cancer and emerging host-pathogen interactions. Here, we review progress in the development of peptides, peptidomimetics and small molecules designed to regulate TIR-dependent signaling in the context of recent advances in structural and molecular studies of TIR domain proteins and their interactions. Keywords: Toll-like receptors, TIR domain, Innate Immunity, NF-κB, Interleukin receptors, peptides, peptidomimetics." @default.
• W2333151971 created "2016-06-24" @default.
• W2333151971 creator A5021748155 @default.
• W2333151971 creator A5037693404 @default.
• W2333151971 date "2014-03-31" @default.
• W2333151971 modified "2023-10-04" @default.
• W2333151971 title "Molecular Interactions in Interleukin and Toll-like Receptor Signaling Pathways" @default.
• W2333151971 cites W118616534 @default.
• W2333151971 cites W1483162601 @default.
• W2333151971 cites W1491063910 @default.
• W2333151971 cites W1519843522 @default.
• W2333151971 cites W1524159069 @default.
• W2333151971 cites W1556574075 @default.
• W2333151971 cites W1603808379 @default.
• W2333151971 cites W1793115003 @default.
• W2333151971 cites W1906664533 @default.
• W2333151971 cites W1920324450 @default.
• W2333151971 cites W1928414651 @default.
• W2333151971 cites W1951699079 @default.
• W2333151971 cites W1966772446 @default.
• W2333151971 cites W1966903309 @default.
• W2333151971 cites W1967269498 @default.
• W2333151971 cites W1969354039 @default.
• W2333151971 cites W1970291282 @default.
• W2333151971 cites W1970434640 @default.
• W2333151971 cites W1970809104 @default.
• W2333151971 cites W1972294481 @default.
• W2333151971 cites W1975007025 @default.
• W2333151971 cites W1975840650 @default.
• W2333151971 cites W1976416996 @default.
• W2333151971 cites W1976424894 @default.
• W2333151971 cites W1976681032 @default.
• W2333151971 cites W1978525572 @default.
• W2333151971 cites W1978901379 @default.
• W2333151971 cites W1980000158 @default.
• W2333151971 cites W1980221962 @default.
• W2333151971 cites W1981067516 @default.
• W2333151971 cites W1983342697 @default.
• W2333151971 cites W1984616248 @default.
• W2333151971 cites W1986205407 @default.
• W2333151971 cites W1987257733 @default.
• W2333151971 cites W1987632085 @default.
• W2333151971 cites W1988715482 @default.
• W2333151971 cites W1989517278 @default.
• W2333151971 cites W1991931339 @default.
• W2333151971 cites W1993026721 @default.
• W2333151971 cites W1993211211 @default.
• W2333151971 cites W1996671942 @default.
• W2333151971 cites W1998055077 @default.
• W2333151971 cites W1998435868 @default.
• W2333151971 cites W1998585620 @default.
• W2333151971 cites W1999985571 @default.
• W2333151971 cites W2001256354 @default.
• W2333151971 cites W2001320403 @default.
• W2333151971 cites W2001747259 @default.
• W2333151971 cites W2002637016 @default.
• W2333151971 cites W2002981660 @default.
• W2333151971 cites W2003385732 @default.
• W2333151971 cites W2003913596 @default.
• W2333151971 cites W2005663597 @default.
• W2333151971 cites W2006348886 @default.
• W2333151971 cites W2008045357 @default.
• W2333151971 cites W2010854320 @default.
• W2333151971 cites W2013601771 @default.
• W2333151971 cites W2013988304 @default.
• W2333151971 cites W2014279855 @default.
• W2333151971 cites W2014628941 @default.
• W2333151971 cites W2014968448 @default.
• W2333151971 cites W2015263036 @default.
• W2333151971 cites W2015984607 @default.
• W2333151971 cites W2019630329 @default.
• W2333151971 cites W2019664188 @default.
• W2333151971 cites W2025450536 @default.
• W2333151971 cites W2026046929 @default.
• W2333151971 cites W2028566209 @default.
• W2333151971 cites W2029116670 @default.
• W2333151971 cites W2030428409 @default.
• W2333151971 cites W2030665562 @default.
• W2333151971 cites W2033196033 @default.
• W2333151971 cites W2036657458 @default.
• W2333151971 cites W2036693151 @default.
• W2333151971 cites W2037302598 @default.
• W2333151971 cites W2038894130 @default.
• W2333151971 cites W2040210770 @default.
• W2333151971 cites W2042453895 @default.
• W2333151971 cites W2042482956 @default.
• W2333151971 cites W2042590551 @default.
• W2333151971 cites W2043633262 @default.
• W2333151971 cites W2043765645 @default.
• W2333151971 cites W2046743509 @default.
• W2333151971 cites W2049449151 @default.
• W2333151971 cites W2053189438 @default.
• W2333151971 cites W2053941041 @default.
• W2333151971 cites W2054979063 @default.
• W2333151971 cites W2056354961 @default.
• W2333151971 cites W2056812842 @default.
• W2333151971 cites W2060218189 @default.
• W2333151971 cites W2061319403 @default.

• next