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• W2333195661 abstract "Objective: To evaluate the effects of adipokines and insulin on intracellular calcium concentration ([Ca 2+ ] i ) and pH (pH i ) in human articular chondrocytes from healthy (CHC) and osteoarthritic cartilage (COC). Design: pH i and [Ca 2+ ] i were measured using BCECF and Fura-2 fluorometric probes in CHC and COC under control conditions and following a hypotonic shock. The effects of interleukin-1β (IL1β), tumor necrosis factor-α (TNFα), insulin, leptin, resistin, and adiponectin were assessed. Results: pH i was lower in COC than in CHC. Only IL1β β decreased pH i in both cell types; all the agents enhanced pH i recovery following an ammonium prepulse in CHC, effect that was attenuated by Na + –H + exchanger inhibitors, but they had no effect in COC. Hypotonic shock (HTS) caused a pH i increase, which was significantly smaller in COC. All the hormones attenuated this response and the effect of IL1β was greater. The basal [Ca 2+ ] i was similar in COC and CHC; IL1β, TNFα, and insulin increased the [Ca 2+ ] i , but leptin, resistin, and adiponectin did not. These effects were greater in COC. This [Ca 2+ ] i increase was dependent on extracellular Ca 2+ and attenuated by Na + –Ca 2+ exchanger inhibitors. HTS caused a [Ca 2+ ] i increase, which was inhibited by transient receptor potential vanilloid blockers and attenuated by all the hormones tested with the exception of adiponectin. Conclusions: These findings may help explain the association between obesity and osteoarthritis, in which these hormones are altered. The responses of CHC and COC are different, which suggests that a modification of pH and Ca 2+ homeostasis is part of the osteoarthritis pathophysiology." @default.
• W2333195661 created "2016-06-24" @default.
• W2333195661 creator A5022453564 @default.
• W2333195661 creator A5075613800 @default.
• W2333195661 date "2014-10-08" @default.
• W2333195661 modified "2023-09-29" @default.
• W2333195661 title "Effects of Adipokines and Insulin on Intracellular pH, Calcium Concentration, and Responses to Hypo-Osmolarity in Human Articular Chondrocytes from Healthy and Osteoarthritic Cartilage" @default.
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• W2333195661 doi "https://doi.org/10.1177/1947603514553095" @default.
• W2333195661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4462245" @default.
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• W2333195661 hasPublicationYear "2014" @default.
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