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• W2333335809 startingPage "833" @default.
• W2333335809 abstract "Background Ulcerative colitis (UC) is a chronic inflammatory disorder of the large bowel. Red grape seed extract (GSE) has antioxidative, anti-inflammatory and antimicrobial activities. Aim of the work This study was designed to evaluate the protective properties of GSE on an animal model of acetic acid-induced UC. Materials and methods Rats were divided into three groups: group I – the control group; group II – the UC group in which UC was induced by a single intracolonic injection of 2▒ml of 3% acetic acid; and group III – the GSE-treated group in which rats were administered GSE at 400▒mg/kg/day, orally for 4 days, after induction of UC. Colon sections were subjected to H&E, and immunohistochemical staining of vascular endothelial growth factor (VEGF) and α-smooth muscle actin (α-SMA). Tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-10 were determined in blood by enzyme-linked immunosorbent assay. Results The UC group showed patchy mucosal ulceration, mononuclear cell infiltration extending to the muscularis externa, increased blood vessels in the mucosa and wide separation of muscle fibers in the muscularis externa. UC significantly increased the plasma levels of proinflammatory cytokines TNF-α and IL-6 and significantly decreased immunoregulatory cytokine IL-10 level in plasma. On histologic assessment it was observed that GSE protected the colon from acetic acid-induced UC by preserving colonic crypts and their lining epithelium while decreasing mononuclear cell infiltration. This histological improvement was associated with a significant decrease in the plasma levels of TNF-α and IL-6 and a significant increase in plasma IL-10 level. Moreover, GSE significantly decreased the VEGF and α-SMA immunostaining in colonic tissues as compared with the UC group. Conclusion This study proved the protective effect of GSE in experimentally induced UC in rats." @default.
• W2333335809 created "2016-06-24" @default.
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• W2333335809 date "2012-12-01" @default.
• W2333335809 modified "2023-09-26" @default.
• W2333335809 title "The effect of methotrexate on the fallopian tubes of adult albino rats" @default.
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• W2333335809 doi "https://doi.org/10.1097/01.ehx.0000421474.49893.73" @default.
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