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• W2333339917 abstract "Background :T he surfactant specific proteins, SP-B and SP-C are believed to be important regulators of the surfactant function and homeostasis. Since acute respiratory distress syndrome(ARDS) is usually viewed as the functional and morphological expression of a similar underlying lung injury caused by a variety of insults, and since abnormalities in the surfactant function have been described in ARDS, the authors investigated the different effects of endotoxin and thiourea on the accumulation of mRNA encoding SP-B and SP-C. Methods : Sprague-Dawley rats were given 5 mg/kg of an intraperitoneal endotoxin from Salmonella enteritidis and 3.5 mg/kg intraperitoneal thiourea and were sacrificed at different time periods. Results : 1. The SP-B mRNA levels 6 and 24 hours after the 5 ㎎/㎏ endotoxin treatment was significantly reduced by 26.1% and 50%, respectively(P<0.01, P<0.001). 2. The SP-B mRNA levels 24 hours after the 3.5 ㎎/㎏ thiourea treatment was reduced by 9.8% and 12.5%, respectively. 3. The SP-C mRNA levels 6 and 24 hours after the 5 ㎎/㎏ endotoxin treatment was significantly reduced by 38.7% and 53.6%, respectively(P<0.01, P<0.001). 4. The SP-C mRNA level 6 hours after the 3.5 ㎎/㎏ thiourea treatment was reduced by 22.8%(P<0.05)." @default.
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• W2333339917 date "2003-01-01" @default.
• W2333339917 modified "2023-09-24" @default.
• W2333339917 title "Gene Expression of Surfactant Protein B and C in Endotoxin and Thiourea Treated Rats" @default.
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• W2333339917 doi "https://doi.org/10.4046/trd.2003.54.5.510" @default.
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