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- W2333420123 abstract "The influence of base pair size and shape on the fidelity of DNA polymerase-mediated extension past lesion-containing mispairs was examined. Primer extension analysis was performed with synthetic nucleosides paired opposite the pro-mutagenic DNA lesion O6-benzylguanine (O6-BnG). These data indicate that the error-prone DNA polymerase IV (Dpo4) inefficiently extended past the larger Peri:O6-BnG base pair, and in contrast, error-free extension was observed for the smaller BIM:O6-BnG base pair. Steady-state kinetic analysis revealed that Dpo4 catalytic efficiency was strongly influenced by the primer:template base pair. Compared to the C:G pair, a 1.9- and 79 000-fold reduction in Dpo4 efficiency was observed for terminal C:O6-BnG and BIM:G base pairs respectively. These results demonstrate the impact of geometrical size and shape on polymerase-mediated mispair extension." @default.
- W2333420123 created "2016-06-24" @default.
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- W2333420123 date "2013-04-17" @default.
- W2333420123 modified "2023-10-02" @default.
- W2333420123 title "Tolerance of Base Pair Size and Shape in Postlesion DNA Synthesis" @default.
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- W2333420123 doi "https://doi.org/10.1021/ja311434s" @default.
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