FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333437834> ?p ?o ?g. }

• W2333437834 endingPage "E426" @default.
• W2333437834 startingPage "E417" @default.
• W2333437834 abstract "A series of interrelated biochemical and functional defects, induced by hyperglycemia, associated with intracellular depletion of D-myo-inositol, and corrected by aldose reductase inhibitors, have been ascribed to abnormal phosphoinositide metabolism in several tissues prone to diabetic complications. However, reductions in tissue D-myo-inositol content are not universally found in complications-prone diabetic tissues, and direct mass-action effects of cellular D-myo-inositol depletion on the critical CDPdiacylglycerol-inositol 3-phosphatidyltransferase (PI synthase; EC 2.7.8.11) step have never been shown conclusively in relevant cells. The studies reported here simultaneously estimated the chemical mass of CDP diglyceride by equilibrium labeling with 5-[3H]cytidine and phosphoinositide biosynthesis by the incorporation of [32P]orthophosphate into phosphoinositide. This was done to assess the degree of inhibition of PI synthase under various degrees of D-myo-inositol depletion and sorbitol accumulation induced by glucose and other metabolic manipulations in cultured human retinal pigment epithelial cells, a new in vitro model for diabetic complications. The results suggest that sorbitol accumulation limits the PI synthase reaction in these cells by selectively depleting specific intracellular pools of D-myo-inositol and/or by possible independent effects of sorbitol on PI synthase." @default.
• W2333437834 created "2016-06-24" @default.
• W2333437834 creator A5012346770 @default.
• W2333437834 creator A5035166714 @default.
• W2333437834 creator A5054498093 @default.
• W2333437834 creator A5077875903 @default.
• W2333437834 creator A5087313131 @default.
• W2333437834 date "1992-04-01" @default.
• W2333437834 modified "2023-09-24" @default.
• W2333437834 title "Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells" @default.
• W2333437834 cites W1670731304 @default.
• W2333437834 cites W1968917601 @default.
• W2333437834 cites W1969306938 @default.
• W2333437834 cites W1973948888 @default.
• W2333437834 cites W1974362576 @default.
• W2333437834 cites W1983315122 @default.
• W2333437834 cites W1996424575 @default.
• W2333437834 cites W1996884513 @default.
• W2333437834 cites W2028057528 @default.
• W2333437834 cites W2029646077 @default.
• W2333437834 cites W2031722337 @default.
• W2333437834 cites W2044934723 @default.
• W2333437834 cites W2047216010 @default.
• W2333437834 cites W2052667951 @default.
• W2333437834 cites W2053866069 @default.
• W2333437834 cites W2057818424 @default.
• W2333437834 cites W2086752312 @default.
• W2333437834 cites W2110127492 @default.
• W2333437834 cites W2124959575 @default.
• W2333437834 cites W2171756335 @default.
• W2333437834 cites W2410255338 @default.
• W2333437834 cites W4242802885 @default.
• W2333437834 cites W6745503 @default.
• W2333437834 doi "https://doi.org/10.1152/ajpendo.1992.262.4.e417" @default.
• W2333437834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1314495" @default.
• W2333437834 hasPublicationYear "1992" @default.
• W2333437834 type Work @default.
• W2333437834 sameAs 2333437834 @default.
• W2333437834 citedByCount "10" @default.
• W2333437834 countsByYear W23334378342014 @default.
• W2333437834 countsByYear W23334378342020 @default.
• W2333437834 crossrefType "journal-article" @default.
• W2333437834 hasAuthorship W2333437834A5012346770 @default.
• W2333437834 hasAuthorship W2333437834A5035166714 @default.
• W2333437834 hasAuthorship W2333437834A5054498093 @default.
• W2333437834 hasAuthorship W2333437834A5077875903 @default.
• W2333437834 hasAuthorship W2333437834A5087313131 @default.
• W2333437834 hasConcept C112243037 @default.
• W2333437834 hasConcept C134018914 @default.
• W2333437834 hasConcept C136502266 @default.
• W2333437834 hasConcept C170493617 @default.
• W2333437834 hasConcept C181199279 @default.
• W2333437834 hasConcept C185592680 @default.
• W2333437834 hasConcept C2776439734 @default.
• W2333437834 hasConcept C2776779347 @default.
• W2333437834 hasConcept C2777427919 @default.
• W2333437834 hasConcept C2780610907 @default.
• W2333437834 hasConcept C2781387506 @default.
• W2333437834 hasConcept C53009064 @default.
• W2333437834 hasConcept C55493867 @default.
• W2333437834 hasConcept C62231903 @default.
• W2333437834 hasConcept C62478195 @default.
• W2333437834 hasConcept C79879829 @default.
• W2333437834 hasConcept C86803240 @default.
• W2333437834 hasConceptScore W2333437834C112243037 @default.
• W2333437834 hasConceptScore W2333437834C134018914 @default.
• W2333437834 hasConceptScore W2333437834C136502266 @default.
• W2333437834 hasConceptScore W2333437834C170493617 @default.
• W2333437834 hasConceptScore W2333437834C181199279 @default.
• W2333437834 hasConceptScore W2333437834C185592680 @default.
• W2333437834 hasConceptScore W2333437834C2776439734 @default.
• W2333437834 hasConceptScore W2333437834C2776779347 @default.
• W2333437834 hasConceptScore W2333437834C2777427919 @default.
• W2333437834 hasConceptScore W2333437834C2780610907 @default.
• W2333437834 hasConceptScore W2333437834C2781387506 @default.
• W2333437834 hasConceptScore W2333437834C53009064 @default.
• W2333437834 hasConceptScore W2333437834C55493867 @default.
• W2333437834 hasConceptScore W2333437834C62231903 @default.
• W2333437834 hasConceptScore W2333437834C62478195 @default.
• W2333437834 hasConceptScore W2333437834C79879829 @default.
• W2333437834 hasConceptScore W2333437834C86803240 @default.
• W2333437834 hasIssue "4" @default.
• W2333437834 hasLocation W23334378341 @default.
• W2333437834 hasLocation W23334378342 @default.
• W2333437834 hasOpenAccess W2333437834 @default.
• W2333437834 hasPrimaryLocation W23334378341 @default.
• W2333437834 hasRelatedWork W1966696704 @default.
• W2333437834 hasRelatedWork W1975707132 @default.
• W2333437834 hasRelatedWork W2007855280 @default.
• W2333437834 hasRelatedWork W2015922194 @default.
• W2333437834 hasRelatedWork W2023716052 @default.
• W2333437834 hasRelatedWork W2032332840 @default.
• W2333437834 hasRelatedWork W2087069990 @default.
• W2333437834 hasRelatedWork W2291181753 @default.
• W2333437834 hasRelatedWork W2333437834 @default.
• W2333437834 hasRelatedWork W2417664702 @default.
• W2333437834 hasVolume "262" @default.
• W2333437834 isParatext "false" @default.

• next