Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333501875> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2333501875 endingPage "634" @default.
- W2333501875 startingPage "631" @default.
- W2333501875 abstract "Thiamphenicol glycinate acetylcysteinate (TGA, CAS 20192-91-0) is a water soluble ester of thiamphenicol (TAP) that allows a rapid utilization by the systemic route but also a direct local action when used as aerosol. To assess the efficacy of aerosolized TGA in the treatment of experimental pneumonia in mice, we compared its in vivo activity with that of thiamphenicol glycinate hydrochloride (TG), erythromycin (ERT) and amoxicillin (AMX), the last two compounds being more active in vitro than TAP. TGA, administered by aerosol route, showed better efficacy than the aerosolized TG, particularly as far as survival rate is concerned, and was significantly more potent than ERT and similar to AMX either administered by oral route. No significantly different therapeutic efficacy was observed when TGA was parenterally administered. The rapid release, at the site of infection, of TAP and N-acetylcysteine and the favourable pharmacokinetic properties of TGA accounted in large part for its high therapeutic efficacy against Streptococcus pyogenes pneumonia." @default.
- W2333501875 created "2016-06-24" @default.
- W2333501875 creator A5033715385 @default.
- W2333501875 creator A5053713459 @default.
- W2333501875 creator A5058863464 @default.
- W2333501875 creator A5087031074 @default.
- W2333501875 creator A5091482618 @default.
- W2333501875 date "2011-12-28" @default.
- W2333501875 modified "2023-09-30" @default.
- W2333501875 title "Activity of Aerosol Thiamphenicol Glycinate Acetylcysteinate in a Mouse Model of S. pyogenes Pneumonia" @default.
- W2333501875 doi "https://doi.org/10.1055/s-0031-1300474" @default.
- W2333501875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10442213" @default.
- W2333501875 hasPublicationYear "2011" @default.
- W2333501875 type Work @default.
- W2333501875 sameAs 2333501875 @default.
- W2333501875 citedByCount "3" @default.
- W2333501875 crossrefType "journal-article" @default.
- W2333501875 hasAuthorship W2333501875A5033715385 @default.
- W2333501875 hasAuthorship W2333501875A5053713459 @default.
- W2333501875 hasAuthorship W2333501875A5058863464 @default.
- W2333501875 hasAuthorship W2333501875A5087031074 @default.
- W2333501875 hasAuthorship W2333501875A5091482618 @default.
- W2333501875 hasConcept C126322002 @default.
- W2333501875 hasConcept C150903083 @default.
- W2333501875 hasConcept C185592680 @default.
- W2333501875 hasConcept C207001950 @default.
- W2333501875 hasConcept C2776954882 @default.
- W2333501875 hasConcept C2777728207 @default.
- W2333501875 hasConcept C2777914695 @default.
- W2333501875 hasConcept C2778473333 @default.
- W2333501875 hasConcept C2780206985 @default.
- W2333501875 hasConcept C42219234 @default.
- W2333501875 hasConcept C501593827 @default.
- W2333501875 hasConcept C55493867 @default.
- W2333501875 hasConcept C71924100 @default.
- W2333501875 hasConcept C82085835 @default.
- W2333501875 hasConcept C86803240 @default.
- W2333501875 hasConcept C89423630 @default.
- W2333501875 hasConcept C98274493 @default.
- W2333501875 hasConceptScore W2333501875C126322002 @default.
- W2333501875 hasConceptScore W2333501875C150903083 @default.
- W2333501875 hasConceptScore W2333501875C185592680 @default.
- W2333501875 hasConceptScore W2333501875C207001950 @default.
- W2333501875 hasConceptScore W2333501875C2776954882 @default.
- W2333501875 hasConceptScore W2333501875C2777728207 @default.
- W2333501875 hasConceptScore W2333501875C2777914695 @default.
- W2333501875 hasConceptScore W2333501875C2778473333 @default.
- W2333501875 hasConceptScore W2333501875C2780206985 @default.
- W2333501875 hasConceptScore W2333501875C42219234 @default.
- W2333501875 hasConceptScore W2333501875C501593827 @default.
- W2333501875 hasConceptScore W2333501875C55493867 @default.
- W2333501875 hasConceptScore W2333501875C71924100 @default.
- W2333501875 hasConceptScore W2333501875C82085835 @default.
- W2333501875 hasConceptScore W2333501875C86803240 @default.
- W2333501875 hasConceptScore W2333501875C89423630 @default.
- W2333501875 hasConceptScore W2333501875C98274493 @default.
- W2333501875 hasIssue "07" @default.
- W2333501875 hasLocation W23335018751 @default.
- W2333501875 hasLocation W23335018752 @default.
- W2333501875 hasOpenAccess W2333501875 @default.
- W2333501875 hasPrimaryLocation W23335018751 @default.
- W2333501875 hasRelatedWork W1969857730 @default.
- W2333501875 hasRelatedWork W1986513215 @default.
- W2333501875 hasRelatedWork W2002847765 @default.
- W2333501875 hasRelatedWork W2011388652 @default.
- W2333501875 hasRelatedWork W2017176145 @default.
- W2333501875 hasRelatedWork W2024139076 @default.
- W2333501875 hasRelatedWork W2025093570 @default.
- W2333501875 hasRelatedWork W2033247911 @default.
- W2333501875 hasRelatedWork W2037633500 @default.
- W2333501875 hasRelatedWork W2037736377 @default.
- W2333501875 hasRelatedWork W2041804566 @default.
- W2333501875 hasRelatedWork W2042909955 @default.
- W2333501875 hasRelatedWork W2068819459 @default.
- W2333501875 hasRelatedWork W2083310060 @default.
- W2333501875 hasRelatedWork W2088968396 @default.
- W2333501875 hasRelatedWork W2104005606 @default.
- W2333501875 hasRelatedWork W2108928782 @default.
- W2333501875 hasRelatedWork W2113165145 @default.
- W2333501875 hasRelatedWork W2116224908 @default.
- W2333501875 hasRelatedWork W2441085073 @default.
- W2333501875 hasVolume "49" @default.
- W2333501875 isParatext "false" @default.
- W2333501875 isRetracted "false" @default.
- W2333501875 magId "2333501875" @default.
- W2333501875 workType "article" @default.