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- W2333536621 abstract "We tested the hypothesis that proton magnetic resonance spectroscopic imaging ( 1 H-MRSI) can be used as a supportive diagnostic tool to differentiate clinically stable brain tumors from those progressing as a result of either low-to-high grade malignant transformation or of post-therapeutic recurrence. Twenty-seven patients with histologically verified cerebral gliomas were studied repeatedly with 1 H-MRSI over a period of 3.5 years. At the time of each 1 H-MRSI study, clinical examination, MRI, positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG), and biopsy findings (when available) were used to categorize each patient as being either «stable» or «progressive». Measures of the between-studies percent changes in the choline 1 H-MRSI signal intensity, obtained without knowledge of the clinical categorization, segregated the groups with a high degree of statistical significance. All progressive cases showed a between-studies choline signal increase of more than 45%, while all stable cases showed an elevation of less than 35%, no change, or even a decreased signal. We conclude that increased choline coincides with malignant degeneration of cerebral gliomas, and therefore, may possibly be used as a supportive indicator of malignant degeneration of these neoplasms." @default.
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- W2333536621 date "1997-10-01" @default.
- W2333536621 modified "2023-10-16" @default.
- W2333536621 title "L'aumento del segnale di colina coincide con la trasformazione maligna dei gliomi cerebrali: Studio longitidinale con imaging di spettroscopia protonica in risonanza magnetica" @default.
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- W2333536621 doi "https://doi.org/10.1177/19714009970100s205" @default.
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