FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333611704> ?p ?o ?g. }

• W2333611704 endingPage "2116" @default.
• W2333611704 startingPage "2108" @default.
• W2333611704 abstract "SUMMARY The heart excitor (HE) motor neuron in the leech Hirudo releases acetylcholine (ACh) and a peptide, FMRFamide, to regulate the contractile activity of the heart tube and associated side vessels. Consistent with Dale's principle, it was assumed that both neurotransmitters were localized to all presynaptic varicosities. However, we found discrete peptide-positive and peptide-negative varicosities associated with particular sites of innervation on the heart tube. We produced dual-labeled HE neurons by pressure injecting Neurobiotin into single HE cell bodies and applied anti-FMRFamide antibodies on the same preparations. Consistent with initial expectations, peptide-labeled varicosities were numerous and widely distributed along the heart tube and at one of the three side vessels, the latero-abdominal vessel. Nevertheless, some Neurobiotin-labeled varicosities along the heart tube lacked peptide label entirely. Moreover, there were dense and distinct peptide-negative innervations at the valve junctions of the latero-dorsal and latero-lateral vessels at each segment. Nevertheless, the peptide label was found in HE axons and varicosities that projected distally along the side vessels. Therefore, the more proximal peptide-negative clusters cannot simply be the result of restricted transport or deficient staining of peptide. Rather, we infer that FMRFamide is transported to (or selectively excluded from) discrete locations and that ACh is present in varicosities that lacked peptide. Such targeting of neurotransmitters could be described using a discrete targeting model of synaptic transmission. Compared with Dale's principle, this model may provide a more complete perspective of chemical communication than previously understood." @default.
• W2333611704 created "2016-06-24" @default.
• W2333611704 creator A5067256731 @default.
• W2333611704 creator A5083064768 @default.
• W2333611704 date "2012-06-15" @default.
• W2333611704 modified "2023-09-24" @default.
• W2333611704 title "Targeting a neuropeptide to discrete regions of the motor arborizations of a single neuron" @default.
• W2333611704 cites W1540812079 @default.
• W2333611704 cites W1562200787 @default.
• W2333611704 cites W1652921363 @default.
• W2333611704 cites W1816117611 @default.
• W2333611704 cites W1946521179 @default.
• W2333611704 cites W1971731748 @default.
• W2333611704 cites W1974276803 @default.
• W2333611704 cites W1979970032 @default.
• W2333611704 cites W1994999924 @default.
• W2333611704 cites W2004218689 @default.
• W2333611704 cites W2015232241 @default.
• W2333611704 cites W2039486626 @default.
• W2333611704 cites W2042604093 @default.
• W2333611704 cites W2047605185 @default.
• W2333611704 cites W2050764295 @default.
• W2333611704 cites W2067364457 @default.
• W2333611704 cites W2071857109 @default.
• W2333611704 cites W2073929966 @default.
• W2333611704 cites W2085068433 @default.
• W2333611704 cites W2119125561 @default.
• W2333611704 cites W2166656495 @default.
• W2333611704 cites W2186501596 @default.
• W2333611704 cites W2270283363 @default.
• W2333611704 cites W2499731597 @default.
• W2333611704 cites W2885718601 @default.
• W2333611704 cites W3016159578 @default.
• W2333611704 doi "https://doi.org/10.1242/jeb.067603" @default.
• W2333611704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22623199" @default.
• W2333611704 hasPublicationYear "2012" @default.
• W2333611704 type Work @default.
• W2333611704 sameAs 2333611704 @default.
• W2333611704 citedByCount "9" @default.
• W2333611704 countsByYear W23336117042012 @default.
• W2333611704 countsByYear W23336117042013 @default.
• W2333611704 countsByYear W23336117042015 @default.
• W2333611704 countsByYear W23336117042016 @default.
• W2333611704 countsByYear W23336117042020 @default.
• W2333611704 countsByYear W23336117042021 @default.
• W2333611704 countsByYear W23336117042023 @default.
• W2333611704 crossrefType "journal-article" @default.
• W2333611704 hasAuthorship W2333611704A5067256731 @default.
• W2333611704 hasAuthorship W2333611704A5083064768 @default.
• W2333611704 hasBestOaLocation W23336117041 @default.
• W2333611704 hasConcept C105702510 @default.
• W2333611704 hasConcept C118303440 @default.
• W2333611704 hasConcept C134018914 @default.
• W2333611704 hasConcept C136764020 @default.
• W2333611704 hasConcept C169760540 @default.
• W2333611704 hasConcept C170493617 @default.
• W2333611704 hasConcept C180746962 @default.
• W2333611704 hasConcept C200170125 @default.
• W2333611704 hasConcept C2775910092 @default.
• W2333611704 hasConcept C2778794669 @default.
• W2333611704 hasConcept C2779281246 @default.
• W2333611704 hasConcept C2781158288 @default.
• W2333611704 hasConcept C41008148 @default.
• W2333611704 hasConcept C55493867 @default.
• W2333611704 hasConcept C86803240 @default.
• W2333611704 hasConceptScore W2333611704C105702510 @default.
• W2333611704 hasConceptScore W2333611704C118303440 @default.
• W2333611704 hasConceptScore W2333611704C134018914 @default.
• W2333611704 hasConceptScore W2333611704C136764020 @default.
• W2333611704 hasConceptScore W2333611704C169760540 @default.
• W2333611704 hasConceptScore W2333611704C170493617 @default.
• W2333611704 hasConceptScore W2333611704C180746962 @default.
• W2333611704 hasConceptScore W2333611704C200170125 @default.
• W2333611704 hasConceptScore W2333611704C2775910092 @default.
• W2333611704 hasConceptScore W2333611704C2778794669 @default.
• W2333611704 hasConceptScore W2333611704C2779281246 @default.
• W2333611704 hasConceptScore W2333611704C2781158288 @default.
• W2333611704 hasConceptScore W2333611704C41008148 @default.
• W2333611704 hasConceptScore W2333611704C55493867 @default.
• W2333611704 hasConceptScore W2333611704C86803240 @default.
• W2333611704 hasIssue "12" @default.
• W2333611704 hasLocation W23336117041 @default.
• W2333611704 hasLocation W23336117042 @default.
• W2333611704 hasOpenAccess W2333611704 @default.
• W2333611704 hasPrimaryLocation W23336117041 @default.
• W2333611704 hasRelatedWork W1997954244 @default.
• W2333611704 hasRelatedWork W1998990062 @default.
• W2333611704 hasRelatedWork W2004356333 @default.
• W2333611704 hasRelatedWork W2016172719 @default.
• W2333611704 hasRelatedWork W2078191693 @default.
• W2333611704 hasRelatedWork W2083213382 @default.
• W2333611704 hasRelatedWork W2085736981 @default.
• W2333611704 hasRelatedWork W2140826708 @default.
• W2333611704 hasRelatedWork W2333611704 @default.
• W2333611704 hasRelatedWork W2921730246 @default.
• W2333611704 hasVolume "215" @default.
• W2333611704 isParatext "false" @default.
• W2333611704 isRetracted "false" @default.

• next