FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333660632> ?p ?o ?g. }

• W2333660632 endingPage "1890" @default.
• W2333660632 startingPage "1881" @default.
• W2333660632 abstract "Palladium(II) complexes of glycoconjugated porphyrin and pyrrolidine-fused chlorin were prepared to examine sugar and heavy atom effects on in vitro photocytotoxicity. Cellular uptake into HeLa cells was enhanced by introducing sugar units regardless of other features, such as the central ion (free base or palladium(II) ion) and the ring structure (porphyrin or chlorin). The palladium(II) complex of glycoconjugated pyrrolidine-fused chlorin (PdPC2) exerted an excellent degree of photocytotoxicity not only on HeLa cells, but also on metastatic B16-BL6 cells, weakly metastatic B16F1 cells, and metastatic 4T1 cells. However, free-base glycoconjugated pyrrolidine-fused chlorin (PC2) also exerted similar or much higher photocytotoxicity rather than PdPC2. Therefore, the palladium(II) ion did not improve the in vitro photocytotoxicity of PC2. The enhanced singlet oxygen generation of palladium(II) complexes (i.e., the heavy atom effect) was confirmed at least in O2-saturated D2O. In addition, the formation of hydrogen peroxide and hydroxyl radical were also detected in O2-saturated phosphate buffered saline. However, the reactive oxygen species (ROS) generation efficiency, which is the product of the (relative) quantum yield of each ROS and the light absorbing ability, did not fit the trends of photocytotoxicity seen for the photosensitizers. In our glycoconjugated photosensitizers tested, the best indicator of the photocytotoxicity was found to be the light absorbing ability (namely, the oscillator strength in the wavelength region applied in the photocytotoxicity test). These results indicated that photochemical characteristics of glycoconjugated photosensitizers were notably susceptible to the microenvironment. The biological characteristics, such as the sugar effect, were a much more reliable approach to improving the photocytotoxicity of photosensitizers." @default.
• W2333660632 created "2016-06-24" @default.
• W2333660632 creator A5003491720 @default.
• W2333660632 creator A5006043249 @default.
• W2333660632 creator A5012890443 @default.
• W2333660632 creator A5014444984 @default.
• W2333660632 creator A5016780228 @default.
• W2333660632 creator A5022600362 @default.
• W2333660632 creator A5035723665 @default.
• W2333660632 creator A5044705478 @default.
• W2333660632 creator A5051292777 @default.
• W2333660632 creator A5053693039 @default.
• W2333660632 creator A5063687473 @default.
• W2333660632 creator A5074828944 @default.
• W2333660632 date "2012-09-10" @default.
• W2333660632 modified "2023-10-18" @default.
• W2333660632 title "Sugar and Heavy Atom Effects of Glycoconjugated Chlorin Palladium Complex on Photocytotoxicity" @default.
• W2333660632 cites W1969109645 @default.
• W2333660632 cites W1971379334 @default.
• W2333660632 cites W1972964752 @default.
• W2333660632 cites W1981368152 @default.
• W2333660632 cites W1986506119 @default.
• W2333660632 cites W1987299742 @default.
• W2333660632 cites W1991805694 @default.
• W2333660632 cites W2001362879 @default.
• W2333660632 cites W2004448189 @default.
• W2333660632 cites W2008877407 @default.
• W2333660632 cites W2009039194 @default.
• W2333660632 cites W2009677760 @default.
• W2333660632 cites W2009791254 @default.
• W2333660632 cites W2009952756 @default.
• W2333660632 cites W2014878754 @default.
• W2333660632 cites W2020182601 @default.
• W2333660632 cites W2036058630 @default.
• W2333660632 cites W2041685462 @default.
• W2333660632 cites W2042664068 @default.
• W2333660632 cites W2049995825 @default.
• W2333660632 cites W2052168361 @default.
• W2333660632 cites W2054496327 @default.
• W2333660632 cites W2059164919 @default.
• W2333660632 cites W2062789585 @default.
• W2333660632 cites W2075178966 @default.
• W2333660632 cites W2079277846 @default.
• W2333660632 cites W2080710543 @default.
• W2333660632 cites W2095472229 @default.
• W2333660632 cites W2106803457 @default.
• W2333660632 cites W2107857160 @default.
• W2333660632 cites W2115715447 @default.
• W2333660632 cites W2139239203 @default.
• W2333660632 cites W2163588530 @default.
• W2333660632 cites W2313608509 @default.
• W2333660632 cites W2318320836 @default.
• W2333660632 cites W2505343817 @default.
• W2333660632 cites W2952566998 @default.
• W2333660632 cites W4251884710 @default.
• W2333660632 doi "https://doi.org/10.1021/bc300223j" @default.
• W2333660632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22946640" @default.
• W2333660632 hasPublicationYear "2012" @default.
• W2333660632 type Work @default.
• W2333660632 sameAs 2333660632 @default.
• W2333660632 citedByCount "30" @default.
• W2333660632 countsByYear W23336606322013 @default.
• W2333660632 countsByYear W23336606322014 @default.
• W2333660632 countsByYear W23336606322015 @default.
• W2333660632 countsByYear W23336606322016 @default.
• W2333660632 countsByYear W23336606322017 @default.
• W2333660632 countsByYear W23336606322018 @default.
• W2333660632 countsByYear W23336606322019 @default.
• W2333660632 countsByYear W23336606322020 @default.
• W2333660632 countsByYear W23336606322021 @default.
• W2333660632 countsByYear W23336606322022 @default.
• W2333660632 countsByYear W23336606322023 @default.
• W2333660632 crossrefType "journal-article" @default.
• W2333660632 hasAuthorship W2333660632A5003491720 @default.
• W2333660632 hasAuthorship W2333660632A5006043249 @default.
• W2333660632 hasAuthorship W2333660632A5012890443 @default.
• W2333660632 hasAuthorship W2333660632A5014444984 @default.
• W2333660632 hasAuthorship W2333660632A5016780228 @default.
• W2333660632 hasAuthorship W2333660632A5022600362 @default.
• W2333660632 hasAuthorship W2333660632A5035723665 @default.
• W2333660632 hasAuthorship W2333660632A5044705478 @default.
• W2333660632 hasAuthorship W2333660632A5051292777 @default.
• W2333660632 hasAuthorship W2333660632A5053693039 @default.
• W2333660632 hasAuthorship W2333660632A5063687473 @default.
• W2333660632 hasAuthorship W2333660632A5074828944 @default.
• W2333660632 hasConcept C161790260 @default.
• W2333660632 hasConcept C178790620 @default.
• W2333660632 hasConcept C185592680 @default.
• W2333660632 hasConcept C202751555 @default.
• W2333660632 hasConcept C2777366897 @default.
• W2333660632 hasConcept C2777516457 @default.
• W2333660632 hasConcept C2778178086 @default.
• W2333660632 hasConcept C2778851528 @default.
• W2333660632 hasConcept C2779480358 @default.
• W2333660632 hasConcept C2781323092 @default.
• W2333660632 hasConcept C48349386 @default.
• W2333660632 hasConcept C502130503 @default.
• W2333660632 hasConcept C540031477 @default.

• next