FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2333671516> ?p ?o ?g. }

• W2333671516 endingPage "3079" @default.
• W2333671516 startingPage "3067" @default.
• W2333671516 abstract "Rett syndrome (RTT) patients suffer from respiratory arrhythmias with frequent apneas causing intermittent hypoxia. In a RTT mouse model (methyl-CpG-binding protein 2-deficient mice; Mecp2(-/y)) we recently discovered an enhanced hippocampal susceptibility to hypoxia and hypoxia-induced spreading depression (HSD). In the present study we investigated whether this also applies to infant Mecp2(-/y) brain stem, which could become life-threatening due to failure of cardiorespiratory control. HSD most reliably occurred in the nucleus of the solitary tract (NTS) and the spinal trigeminal nucleus (Sp5). HSD susceptibility of the Mecp2(-/y) NTS and Sp5 was increased on 8 mM K(+)-mediated conditioning. 5-HT(1A) receptor stimulation with 8-hydroxy-2-(di-propylamino)tetralin (8-OH-DPAT) postponed HSD by up to 40%, mediating genotype-independent protection. The deleterious impact of HSD on in vitro respiration became obvious in rhythmically active slices, where HSD propagation into the pre-Bötzinger complex (pre-BötC) immediately arrested the respiratory rhythm. Compared with wild-type, the Mecp2(-/y) pre-BötC was invaded less frequently by HSD, but if so, HSD occurred earlier. On reoxygenation, in vitro rhythms reappeared with increased frequency, which was less pronounced in Mecp2(-/y) slices. 8-OH-DPAT increased respiratory frequency but failed to postpone HSD in the pre-BötC. Repetitive hypoxia facilitated posthypoxic recovery only if HSD occurred. In 57% of Mecp2(-/y) slices, however, HSD spared the pre-BötC. Although this occasionally promoted residual hypoxic respiratory activity (gasping), it also prolonged the posthypoxic recovery, and thus the absence of central inspiratory drive, which in vivo would lengthen respiratory arrest. In view of the breathing disorders in RTTs, the increased hypoxia susceptibility of MeCP2-deficient brain stem potentially contributes to life-threatening disturbances of cardiorespiratory control." @default.
• W2333671516 created "2016-06-24" @default.
• W2333671516 creator A5021487531 @default.
• W2333671516 creator A5029600467 @default.
• W2333671516 creator A5056675989 @default.
• W2333671516 creator A5058212089 @default.
• W2333671516 creator A5075194061 @default.
• W2333671516 date "2011-06-01" @default.
• W2333671516 modified "2023-10-16" @default.
• W2333671516 title "Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia" @default.
• W2333671516 cites W146097556 @default.
• W2333671516 cites W1559742681 @default.
• W2333671516 cites W173414542 @default.
• W2333671516 cites W1901761516 @default.
• W2333671516 cites W1926041874 @default.
• W2333671516 cites W1966688219 @default.
• W2333671516 cites W1978533353 @default.
• W2333671516 cites W1979223448 @default.
• W2333671516 cites W1980723823 @default.
• W2333671516 cites W1982892406 @default.
• W2333671516 cites W1983210704 @default.
• W2333671516 cites W1983824504 @default.
• W2333671516 cites W1984571713 @default.
• W2333671516 cites W1990771197 @default.
• W2333671516 cites W1995577873 @default.
• W2333671516 cites W1997041986 @default.
• W2333671516 cites W2004661192 @default.
• W2333671516 cites W2011135037 @default.
• W2333671516 cites W2011395006 @default.
• W2333671516 cites W2012726689 @default.
• W2333671516 cites W2014408116 @default.
• W2333671516 cites W2016151414 @default.
• W2333671516 cites W2016624327 @default.
• W2333671516 cites W2019864436 @default.
• W2333671516 cites W2029078782 @default.
• W2333671516 cites W2029338036 @default.
• W2333671516 cites W2030424501 @default.
• W2333671516 cites W2034226385 @default.
• W2333671516 cites W2034510872 @default.
• W2333671516 cites W2035488025 @default.
• W2333671516 cites W2037688283 @default.
• W2333671516 cites W2039276157 @default.
• W2333671516 cites W2039831063 @default.
• W2333671516 cites W2040558433 @default.
• W2333671516 cites W2046013863 @default.
• W2333671516 cites W2050201619 @default.
• W2333671516 cites W2050714001 @default.
• W2333671516 cites W2053302747 @default.
• W2333671516 cites W2063630842 @default.
• W2333671516 cites W2063840478 @default.
• W2333671516 cites W2064286283 @default.
• W2333671516 cites W2066189743 @default.
• W2333671516 cites W2066485803 @default.
• W2333671516 cites W2068358888 @default.
• W2333671516 cites W2069194632 @default.
• W2333671516 cites W2069429850 @default.
• W2333671516 cites W2076422538 @default.
• W2333671516 cites W2082405299 @default.
• W2333671516 cites W2082787641 @default.
• W2333671516 cites W2088319884 @default.
• W2333671516 cites W2088947308 @default.
• W2333671516 cites W2088996542 @default.
• W2333671516 cites W2089633679 @default.
• W2333671516 cites W2091952287 @default.
• W2333671516 cites W2093428170 @default.
• W2333671516 cites W2094282643 @default.
• W2333671516 cites W2100482324 @default.
• W2333671516 cites W2104532925 @default.
• W2333671516 cites W2107621900 @default.
• W2333671516 cites W2110911232 @default.
• W2333671516 cites W2127311839 @default.
• W2333671516 cites W2128577307 @default.
• W2333671516 cites W2136957534 @default.
• W2333671516 cites W2139411439 @default.
• W2333671516 cites W2144759791 @default.
• W2333671516 cites W2148200514 @default.
• W2333671516 cites W2149195281 @default.
• W2333671516 cites W2152668149 @default.
• W2333671516 cites W2153195998 @default.
• W2333671516 cites W2160619028 @default.
• W2333671516 cites W2162254167 @default.
• W2333671516 cites W2168126378 @default.
• W2333671516 cites W2170506050 @default.
• W2333671516 cites W2208080011 @default.
• W2333671516 cites W2238569566 @default.
• W2333671516 cites W2404121715 @default.
• W2333671516 cites W46964427 @default.
• W2333671516 doi "https://doi.org/10.1152/jn.00822.2010" @default.
• W2333671516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21471397" @default.
• W2333671516 hasPublicationYear "2011" @default.
• W2333671516 type Work @default.
• W2333671516 sameAs 2333671516 @default.
• W2333671516 citedByCount "14" @default.
• W2333671516 countsByYear W23336715162012 @default.
• W2333671516 countsByYear W23336715162013 @default.
• W2333671516 countsByYear W23336715162015 @default.
• W2333671516 countsByYear W23336715162017 @default.
• W2333671516 countsByYear W23336715162020 @default.

• next