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• W2333749295 abstract "Event Abstract Back to Event Set-switching in obsessive-compulsive disorder: An ERP comparison with panic disorder. Susan J. Thomas1, 2*, Craig J. Gonsalvez2, 3 and Stuart J. Johnstone2, 3 1 University of Wollongong, Graduate School of Medicine, Australia 2 Brain & Behaviour Research Institute, University of Wollongong, Australia 3 School of Psychology, University of Wollongong, Australia Aims: Cognitive flexibility, including the ability to shift adaptively between changing tasks or rules, may be impaired in obsessive-compulsive disorder (OCD), contributing to repetitive symptoms. Brain mechanisms and the specificity of set-shifting difficulties to OCD are inadequately understood. We investigated the neurophysiology of set-shifting in participants with OCD versus healthy and anxious controls. Method: Participants with OCD (n= 20) versus healthy (n= 20) and anxious controls with panic disorder (n= 20) performed a specially designed Go/ NoGo task, where some stimuli had switching, and some had fixed, response requirements. ERPs, response time (RT) and accuracy were compared between groups. Results: Switch costs occurred in terms of higher errors to switching stimuli across participant groups, particularly commission errors to switching NoGo stimuli. For N2, there was a Switch by Go/ NoGo interaction, with the largest N2 amplitude occurring to switching NoGo stimuli. Additionally, N2 latency was longer to switching stimuli. Classic NoGo enlargement and anteriorisation occurred for N2-P3, across groups. Both clinical groups had higher switching versus non-switching P3 amplitude, compared to healthy controls. Additionally, clinical groups shared general RT impairments and atypical topography of N2. Conclusions: We identified similar general deficits and ERP anomalies during task-switching in OCD and panic disorder, precluding OCD-specific interpretations. Both conditions may be characterised by shared anomalies in cognitive flexibility and control. Keywords: set-shifting, OCD, inhibition, ERPs, Panic Disorder, P3, N2 Conference: ASP2013 - 23rd Annual meeting of the Australasian Society for Psychophysiology, Wollongong, Australia, 20 Nov - 22 Nov, 2013. Presentation Type: Oral Presentation Topic: Cognitive control Citation: Thomas SJ, Gonsalvez CJ and Johnstone SJ (2013). Set-switching in obsessive-compulsive disorder: An ERP comparison with panic disorder.. Conference Abstract: ASP2013 - 23rd Annual meeting of the Australasian Society for Psychophysiology. doi: 10.3389/conf.fnhum.2013.213.00016 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Nov 2013; Published Online: 05 Nov 2013. * Correspondence: Dr. Susan J Thomas, University of Wollongong, Graduate School of Medicine, Wollongong, NSW, Australia, sthomas@uow.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Susan J Thomas Craig J Gonsalvez Stuart J Johnstone Google Susan J Thomas Craig J Gonsalvez Stuart J Johnstone Google Scholar Susan J Thomas Craig J Gonsalvez Stuart J Johnstone PubMed Susan J Thomas Craig J Gonsalvez Stuart J Johnstone Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2333749295 title "Set-switching in obsessive-compulsive disorder: An ERP comparison with panic disorder." @default.
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