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• W2333821017 abstract "Objective: The aim of this study was to demonstrate the feasibility of using samples obtained through muscle biopsy to assess a wide range of cellular properties, some of which may be abnormal in myalgia. Given the recent emphasis on the role of excitation-contraction coupling in health and disease, special emphasis is given to the characterization of the properties involved in this process. Design: Tissue samples were obtained from the upper portion of the descending trapezius muscle in three female patients (PAT) with clinically diagnosed myalgia and assessed for a spectrum of properties related to substrate use, energy production, and excitation-contraction coupling and were compared with samples from three healthy controls. Results: At the level of organization of the metabolic pathways, all PAT generally displayed normal activities of enzymes representing the potential for oxidative phosphorylation, glucose phosphorylation, glycolysis, and lactate oxidation. In contrast, a reduced potential was observed in PAT for both fat oxidation (−20%) and high-energy phosphate transfer (−38%). For excitation-contraction coupling, PAT had a compromised sarcoplasmic reticulum maximal Ca2+-ATPase activity (−21%), Ca2+ uptake (−44%), and sarcoplasmic endopleasmic reticulum (SERCA) expression for both SERCA1a (−16%) and SERCA2a (−17%), which were accompanied by a lower phase 2 Ca2+ release (−45%). The Na+-K+-ATPase concentration, the enzyme-regulating membrane excitability via active Na+ and K+ seemed elevated (+25%) in PAT. Conclusions: These results demonstrate the feasibility of analyzing tissue samples for a wide range of properties and provide a rationale for studies examining the cellular basis of myalgia with particular emphasis on sarcoplasmic reticulum Ca2+ cycling, given the latter's role in regulating a wide range of cellular functions." @default.
• W2333821017 created "2016-06-24" @default.
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• W2333821017 date "2011-10-01" @default.
• W2333821017 modified "2023-10-11" @default.
• W2333821017 title "Are Abnormalities in Sarcoplasmic Reticulum Calcium Cycling Properties Involved in Trapezius Myalgia?" @default.
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• W2333821017 doi "https://doi.org/10.1097/phm.0b013e31821f6f1f" @default.
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