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- W2333862867 abstract "Background: Pulmonary vascular resistance (PVR) is known as an index of the management of patients with heart failure and pulmonary hypertension, but the mechanisms of PVR increase are not completely understood. Matrix metalloproteinase (MMP)-2 degrades the extracellular matrix structural proteins. On the other hand, tissue inhibitor of metalloproteinase (TIMP)-2 regulates negatively MMPs. They are key biomarkers of vascular and ventricular remodeling in heart failure. We evaluated the relationships between PVR and MMP-2 and TIMP-2 in patients with chronic heart failure (CHF). Methods: We evaluated 173 heart failure patients who were undergoing invasive hemodynamic study with right cardiac catheterization, retrospectively. PVR was calculated as (mPAP - PCWP)/cardiac output multiplied by 80. Circulating levels of MMP-2 and TIMP-2 were measured by ELISA. We also assessed Atrial natriuretic peptide (ANP) and Brain natriuretic peptide (BNP). Results: PVR had significant positive correlations with serum MMP-2 levels and MMP-2/TIMP-2 ratio (r=0.176, P<0.05 and r=0.441, P<0.01, respectively,Fig1). PVR did not change according to the NYHA functional class. Both levels of ANP and BNP had significant positive correlations with PVR (r=0.174, P<0.05 and r=0.186, P<0.05, respectively). Figure 1 Figure 1 Conclusions: PVR is correlated with MMP-2 and MMP-2/TIMP-2 ratio values in CHF patients. Based on these results, we suggest the balance of MMP-2 and TIMP-2 contribute to the progression of pulmonary vasculature remodeling in patients with CHF." @default.
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- W2333862867 date "2013-08-02" @default.
- W2333862867 modified "2023-10-17" @default.
- W2333862867 title "Correlation between serum matrix metalloproteinase-2/tissue inhibitors of metalloproteinase-2 ratio and elevated pulmonary vascular resistance" @default.
- W2333862867 doi "https://doi.org/10.1093/eurheartj/eht307.p289" @default.
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