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• W2333867360 abstract "Back to table of contents Previous article Next article No AccessAssessment of lineality in bipolar I linkage studiesPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.149.12.1660AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: To assess lineality in families of bipolar I probands, the authors used direct interviews of family members to reclassify families initially categorized as unilineal by family history. METHOD: The families of 1,800 treated bipolar I probands were screened by the family history method with multiple informants. If the proband had one or more affected sibs and one apparently unaffected parent, the parents (and then other available first- and second-degree relatives) were directly interviewed by psychiatrists. RESULTS: Of the 1,800 families screened, 56 were apparently suitable unilineal families with multiple affected members; 46 families were interviewed directly. After interviews with the parents, 12 families (26.1%) were found to be bilineal. Direct interviews of all available relatives in the 34 remaining families revealed that only 22 (47.8% of the 46 interviewed families) were unilineal or probably unilineal and 12 were probably bilineal. The probably bilineal families had a significantly higher proportion of siblings with unipolar disorder. In addition, the affected sibs from the probably bilineal families tended to have earlier onsets but had significantly fewer symptoms in the most severe depressive episode. CONCLUSIONS: Fewer than 50% of bipolar I families appearing unilineal according to family history were found to be unilineal by direct interviews. The phenotypic differences between the affected sibs from the probably bilineal families and those from the unilineal and probably unilineal families suggest differences in genetic mechanisms. These findings highlight the need to systematically assess lineality in all families considered for bipolar I linkage studies and support the preferential inclusion of unilineal families in linkage studies. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byMore assortative mating in US compared to European parents and spouses of patients with bipolar disorder: implications for psychiatric illness in the offspring11 August 2018 | European Archives of Psychiatry and Clinical Neuroscience, Vol. 270, No. 2Bipolar Disorders, Vol. 20, No. 5Current Treatment Options in Psychiatry, Vol. 4, No. 4American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 147B, No. 1Sequence variation in DOCK9 and heterogeneity in bipolar disorderPsychiatric Genetics, Vol. 17, No. 5The Bipolar Disorder Phenome Database: A Resource for Genetic StudiesJames B. Potash, M.D., M.P.H.Jennifer Toolan, M.S.Jo Steele, B.Eng.Erin B. Miller, M.S.Justin Pearl, B.S.Peter P. Zandi, Ph.D.Thomas G. Schulze, M.D.Layla Kassem, Ph.D.Sylvia G. Simpson, M.D., M.P.H.Victor Lopez, M.D.Dean F. MacKinnon, M.D.Francis J. McMahon, M.D.1 August 2007 | American Journal of Psychiatry, Vol. 164, No. 8Genetic Epidemiology, Vol. 30, No. 2The phenotypes of bipolar disorder: relevance for genetic investigations21 June 2005 | Molecular Psychiatry, Vol. 10, No. 9Familial Variation in Episode Frequency in Bipolar Affective DisorderMaria E. Fisfalen, M.D., Thomas G. Schulze, M.D., J. Raymond DePauloJr., M.D., Leslie J. DeGroot, M.D., Judith A. Badner, M.D., and Francis J. McMahon, M.D.1 July 2005 | American Journal of Psychiatry, Vol. 162, No. 7Biological Psychiatry, Vol. 57, No. 6American Journal of Medical Genetics, Vol. 124B, No. 1Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q3322 December 2003 | Molecular Psychiatry, Vol. 9, No. 1Genome-wide scan of bipolar disorder in 65 pedigrees: supportive evidence for linkage at 8q24, 18q22, 4q32, 2p12, and 13q1227 March 2003 | Molecular Psychiatry, Vol. 8, No. 3Biological Psychiatry, Vol. 53, No. 3Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus30 July 2002 | Molecular Psychiatry, Vol. 7, No. 6American Journal of Medical Genetics, Vol. 114, No. 4The Familial Aggregation of Psychotic Symptoms in Bipolar Disorder PedigreesJames B. Potash, M.D., M.P.H., Virginia L. Willour, Ph.D., Yen-Feng Chiu, Ph.D., Sylvia G. Simpson, M.D., M.P.H., Dean F. MacKinnon, M.D., Godfrey D. Pearlson, M.D., J. Raymond DePauloJr., M.D., and Melvin G. McInnis, M.D.1 August 2001 | American Journal of Psychiatry, Vol. 158, No. 8Annals of Medicine, Vol. 33, No. 4Attempted Suicide and Alcoholism in Bipolar Disorder: Clinical and Familial RelationshipsJames B. Potash, M.D., M.P.H., H. Scott Kane, M.D., Yen-feng Chiu, Ph.D., Sylvia G. Simpson, M.D., M.P.H., Dean F. MacKinnon, M.D., Melvin G. McInnis, M.D., Francis J. McMahon, M.D., and J. Raymond DePauloJr., M.D.1 December 2000 | American Journal of Psychiatry, Vol. 157, No. 12Mitochondrial DNA Sequence Diversity in Bipolar Affective DisorderFrancis J. McMahon, , M.D., Yu Sheng Chen, , Ph.D., Satyakam Patel, , B.S., Jason Kokoszka, , B.A., Michael D. Brown, , Ph.D., Antonio Torroni, , Ph.D., J. Raymond DePaulo, , M.D., and Douglas C. Wallace, , Ph.D.1 July 2000 | American Journal of Psychiatry, Vol. 157, No. 7The American Journal of Human Genetics, Vol. 66, No. 1Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree SeriesThe American Journal of Human Genetics, Vol. 61, No. 6Panic disorder with familial bipolar disorderBiological Psychiatry, Vol. 42, No. 2Bipolar Disorder: From Families to Genes1 May 1997 | The Canadian Journal of Psychiatry, Vol. 42, No. 4American Journal of Medical Genetics, Vol. 74, No. 3Human Molecular Genetics, Vol. 6, No. 11American Journal of Medical Genetics, Vol. 67, No. 5Biological Psychiatry, Vol. 40, No. 6Irish Journal of Psychological Medicine, Vol. 13, No. 4Acta Psychiatrica Scandinavica, Vol. 93, No. 5Influence of clinical subtype, sex, and lineality on age at onset of major affective disorder in a family sample1 April 2006 | American Journal of Psychiatry, Vol. 151, No. 2Acta Psychiatrica Scandinavica, Vol. 90, No. 4 Volume 149Issue 12 December 1992Pages 1660-1665 Metrics PDF download History Published online 1 April 2006 Published in print 1 December 1992" @default.
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