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• W2333989258 abstract "Campbell, D. M. and P. K. Rose. Contribution of voltage-dependent potassium channels to the somatic shunt in neck motoneurons of the cat. J. Neurophysiol. 77: 1470–1486, 1997. The specific membrane resistivity of motoneurons at or near the soma ( R ms ) is much lower than the specific membrane resistivity of the dendritic tree ( R md ). The goal of the present experiments was to investigate the contribution of tonically active voltage-dependent potassium channels at or near the soma to the low R ms . These channels were blocked with the use of intracellular injections of cesium. Input resistance ( R N ), R ms / R md , a conductance representing voltage-dependent potassium channels on the soma, G K , and a conductance attributed to damage caused by electrode impalement, G Da , were estimated from voltage responses to a step of current. The effect of intracellular injections of cesium on electrotonic structure was determined with the use of two strategies: 1) a population analysis that compared data from two groups of motoneurons, those recorded with potassium acetate electrodes (control group) and those recorded with cesium acetate electrodes after the motoneurons were loaded with cesium; and 2) an analysis of changes in electrotonic structure that occurred over the course of multiple injections of cesium or during similar periods of time in control cells. R N of control and cesium-loaded motoneurons was similar. Over the course of the recordings, R N of control cells usually increased and this increase was associated with a hyperpolarization. In contrast, increases in R N after successive injections of cesium were closely linked to a depolarization. At corresponding membrane potentials, R ms / R md of cesium-loaded motoneurons was greater than R ms / R md of control motoneurons. Over the course of cesium injections, R ms / R md increased and the membrane potential depolarized. In contrast, increases in R ms / R md observed during the course of recordings from control cells were associated with a hyperpolarization. Compared with control cells at corresponding membrane potentials, G K was less in cesium-loaded cells. Increases in G K that occurred over the course of recordings in control cells were closely coupled to a depolarization. In cesium-loaded cells, G K usually decreased as the cell depolarized during the injections. In control cells, increases in G Da that occurred during the recording period were closely coupled to a depolarization. In contrast, changes in G Da that occurred during cesium injections were not related to the change in membrane potential and did not explain the corresponding changes in R ms / R md and membrane potential. The results of this study indicate that voltage-dependent potassium channels contribute to the somatic shunt (low R ms ) in neck motoneurons and provide a voltage-dependent mechanism for the dynamic regulation of motoneuron electrotonic properties." @default.
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• W2333989258 date "1997-03-01" @default.
• W2333989258 modified "2023-09-27" @default.
• W2333989258 title "Contribution of Voltage-Dependent Potassium Channels to the Somatic Shunt in Neck Motoneurons of the Cat" @default.
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• W2333989258 doi "https://doi.org/10.1152/jn.1997.77.3.1470" @default.
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• W2333989258 hasPublicationYear "1997" @default.
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