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- W2334003478 abstract "Dyslipidemia and oxidative stress were evaluated in patients with polycystic ovarian syndrome. MATERIALS AND METHODS: Total cholesterol, Triglyceride, HDL cholesterol, LDL cholesterol, Malondialdehyde (MDA) and Total antioxidant capacity were measured in serum of PCOS subjects and age matched controls. RESULTS: Study group comprised of 31 women with PCOS and control group with 31 healthy volunteers. Mean serum levels of MDA, Cholesterol, Triglycerides and LDL cholesterol were significantly increased and TAC and HDL cholesterol were significantly decreased in PCOS subjects compared to controls. CONCLUSION: Our results revealed that PCOS is associated with dyslipidemia and altered oxidative status. Women with PCOS would be predicted to be at high risk for dyslipidemia because they have elevated androgen levels and are frequently obese. Moreover, since they are also often hyperinsulinemic and insulin resistant, they would also be expected to be at increased risk for the dyslipidemia associated with insulin resistance. Insulin, rather than androgen, levels correlate best with lipid abnormalities, and suppressing androgen levels does not alter lipid profiles in PCOS. Insulin resistance and hyperinsulinemia are also associated with an atherogenic plasma lipid profile. Elevated plasma insulin concentrations enhance very low density lipoprotein (VLDL) synthesis, leading to hypertriglyceridemia. Progressive elimination of lipid and apolipoproteins from the VLDL particle leads to an increased formation of intermediate-density and low-density lipoproteins, both of which are atherogenic. Last, insulin, independent of its effects on blood pressure and plasma lipids, is known to be atherogenic. The hormone enhances cholesterol transport into arteriolar smooth muscle cells and increases" @default.
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- W2334003478 date "2012-11-16" @default.
- W2334003478 modified "2023-10-17" @default.
- W2334003478 title "MARKERS OF OXIDATIVE STRESS AND SERUM LIPIDS IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME" @default.
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- W2334003478 doi "https://doi.org/10.14260/jemds/123" @default.
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