Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334007493> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2334007493 endingPage "305" @default.
- W2334007493 startingPage "300" @default.
- W2334007493 abstract "The ERCC5 gene plays an important role in the nucleotide excision repair pathway that recognizes and removes platinum-DNA adducts. We aimed to examine whether ERCC5 promoter polymorphisms contribute toward intervariations in the platinum treatment response in patients with advanced non-small-cell lung cancer (NSCLC). We evaluated the association between three tag-single nucleotide polymorphisms in the ERCC5 promoter region (rs2094258, rs751402, and rs2296147, respectively) and the efficacy of chemotherapy in 228 advanced NSCLC patients. We found that the rs751402 AA genotype was associated with a better treatment response [AA vs. AG+GG: odds ratio (OR)=2.74, 95% confidence interval (CI) 1.04-7.26, P=0.036) in all NSCLC patients, which was more evident in the subgroup of patients with squamous cell carcinoma (AA vs. GG: OR=6.40, 95% CI 1.15-35.50, P=0.043; AA vs. AG+GG: OR=6.12, 95% CI 1.15-32.52, P=0.019). No statistically significant association was found between rs2094258 and rs2296147 polymorphisms and treatment response. Our results suggested that the ERCC5 rs751402 AA genotype increased the chemotherapy response in advanced NSCLC, especially in patients with squamous cell carcinoma. Further and larger scale studies are still required to provide more comprehensive information on ERCC5 promoter variations in the clinical outcome of NSCLC patients treated with platinum regimens." @default.
- W2334007493 created "2016-06-24" @default.
- W2334007493 creator A5011540763 @default.
- W2334007493 creator A5060458161 @default.
- W2334007493 creator A5060901085 @default.
- W2334007493 creator A5073070877 @default.
- W2334007493 creator A5090177646 @default.
- W2334007493 date "2013-03-01" @default.
- W2334007493 modified "2023-10-05" @default.
- W2334007493 title "Role of ERCC5 promoter polymorphisms in response to platinum-based chemotherapy in patients with advanced non-small-cell lung cancer" @default.
- W2334007493 cites W1836971821 @default.
- W2334007493 cites W1999027035 @default.
- W2334007493 cites W2035376552 @default.
- W2334007493 cites W2043103956 @default.
- W2334007493 cites W2046317081 @default.
- W2334007493 cites W2050428459 @default.
- W2334007493 cites W2064235474 @default.
- W2334007493 cites W2083592062 @default.
- W2334007493 cites W2099082193 @default.
- W2334007493 cites W2099613936 @default.
- W2334007493 cites W2112483303 @default.
- W2334007493 cites W2119165414 @default.
- W2334007493 cites W2119279196 @default.
- W2334007493 cites W2123857987 @default.
- W2334007493 cites W2130702927 @default.
- W2334007493 cites W2146240398 @default.
- W2334007493 cites W2150507948 @default.
- W2334007493 cites W2167805334 @default.
- W2334007493 cites W2169416147 @default.
- W2334007493 cites W2170454539 @default.
- W2334007493 cites W2333303595 @default.
- W2334007493 doi "https://doi.org/10.1097/cad.0b013e32835bd6ce" @default.
- W2334007493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211354" @default.
- W2334007493 hasPublicationYear "2013" @default.
- W2334007493 type Work @default.
- W2334007493 sameAs 2334007493 @default.
- W2334007493 citedByCount "21" @default.
- W2334007493 countsByYear W23340074932013 @default.
- W2334007493 countsByYear W23340074932014 @default.
- W2334007493 countsByYear W23340074932015 @default.
- W2334007493 countsByYear W23340074932016 @default.
- W2334007493 countsByYear W23340074932017 @default.
- W2334007493 countsByYear W23340074932018 @default.
- W2334007493 countsByYear W23340074932022 @default.
- W2334007493 crossrefType "journal-article" @default.
- W2334007493 hasAuthorship W2334007493A5011540763 @default.
- W2334007493 hasAuthorship W2334007493A5060458161 @default.
- W2334007493 hasAuthorship W2334007493A5060901085 @default.
- W2334007493 hasAuthorship W2334007493A5073070877 @default.
- W2334007493 hasAuthorship W2334007493A5090177646 @default.
- W2334007493 hasConcept C104317684 @default.
- W2334007493 hasConcept C126322002 @default.
- W2334007493 hasConcept C135763542 @default.
- W2334007493 hasConcept C143998085 @default.
- W2334007493 hasConcept C1491633281 @default.
- W2334007493 hasConcept C153209595 @default.
- W2334007493 hasConcept C156957248 @default.
- W2334007493 hasConcept C2776256026 @default.
- W2334007493 hasConcept C2776694085 @default.
- W2334007493 hasConcept C44249647 @default.
- W2334007493 hasConcept C502942594 @default.
- W2334007493 hasConcept C54355233 @default.
- W2334007493 hasConcept C71924100 @default.
- W2334007493 hasConcept C86803240 @default.
- W2334007493 hasConceptScore W2334007493C104317684 @default.
- W2334007493 hasConceptScore W2334007493C126322002 @default.
- W2334007493 hasConceptScore W2334007493C135763542 @default.
- W2334007493 hasConceptScore W2334007493C143998085 @default.
- W2334007493 hasConceptScore W2334007493C1491633281 @default.
- W2334007493 hasConceptScore W2334007493C153209595 @default.
- W2334007493 hasConceptScore W2334007493C156957248 @default.
- W2334007493 hasConceptScore W2334007493C2776256026 @default.
- W2334007493 hasConceptScore W2334007493C2776694085 @default.
- W2334007493 hasConceptScore W2334007493C44249647 @default.
- W2334007493 hasConceptScore W2334007493C502942594 @default.
- W2334007493 hasConceptScore W2334007493C54355233 @default.
- W2334007493 hasConceptScore W2334007493C71924100 @default.
- W2334007493 hasConceptScore W2334007493C86803240 @default.
- W2334007493 hasIssue "3" @default.
- W2334007493 hasLocation W23340074931 @default.
- W2334007493 hasLocation W23340074932 @default.
- W2334007493 hasOpenAccess W2334007493 @default.
- W2334007493 hasPrimaryLocation W23340074931 @default.
- W2334007493 hasRelatedWork W1943617196 @default.
- W2334007493 hasRelatedWork W1992586115 @default.
- W2334007493 hasRelatedWork W2012120628 @default.
- W2334007493 hasRelatedWork W2135480374 @default.
- W2334007493 hasRelatedWork W2263513184 @default.
- W2334007493 hasRelatedWork W2329364306 @default.
- W2334007493 hasRelatedWork W2414000003 @default.
- W2334007493 hasRelatedWork W2912603490 @default.
- W2334007493 hasRelatedWork W2958841296 @default.
- W2334007493 hasRelatedWork W4244872179 @default.
- W2334007493 hasVolume "24" @default.
- W2334007493 isParatext "false" @default.
- W2334007493 isRetracted "false" @default.
- W2334007493 magId "2334007493" @default.
- W2334007493 workType "article" @default.