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- W2334014726 abstract "Absorption of 45Ca2+ was studied in the small and large intestine of the adult male frog Rana pipiens through an in situ intestinal ligated-loop preparation. With a graded series of luminal calcium concentrations, 45Ca uptake into small intestine in March animals is by passive diffusion alone, while in April through June 45Ca uptake in duodenum and jejunoileum follows a curvilinear function that shows a saturable and a nonsaturable component. The duodenal nonsaturable component had a diffusion constant (Kd) of 0.71 ±.09 mL/g/hr. The saturable component followed Michaelis-Menten kinetics, with a saturable flux (Jmax) of 23.9 ± 2.5 μmol/g/h and half-saturation constant (Km) of 9.5 ± 2.1 mM Ca²⁺. Jejunoileum also exhibited nonsaturable and saturable components with a Kd of 0.65 ± 0.09 mL/g/h. Colon exhibited only a passive diffusion uptake pattern with a Kd of 0.40 ± 0.03 mL/g/h, which is significantly lower than that of the small intestine. After 500 μg of vitamin D, duodenal Jmax was elevated to 34.6 ± 5.3 μmol/g/h, while jejunoileum was unchanged at a Jmax of 19.2 ± 1.7 μmol/g/h, and colon maintained a Kd of 0.45 ± 0.03 mL/g/h. Passive diffusion is present in all intestinal segments, with evidence of a low-binding-capacity active transport system in the proximal segment most apparent during April through June. A putative calcium-binding protein may be functionally similar to that of homeotherms; however, the kinetics suggest that it may be structurally dissimilar." @default.
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- W2334014726 date "1995-11-01" @default.
- W2334014726 modified "2023-09-26" @default.
- W2334014726 title "Kinetics of Calcium Absorption in the Small and Large Intestine of the FrogRana pipiens" @default.
- W2334014726 doi "https://doi.org/10.1086/physzool.68.6.30163795" @default.
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