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- W2334023746 abstract "Objective: We examined the role of active cigarette smoking, smoking cessation, and environmental tobacco smoking (ETS) as determinants for pancreatic cancer in a large prospective cohort study. Methods: The Netherlands Cohort Study consisted of 120,852 men and women who completed a baseline questionnaire in 1986. After 16.3 years of follow‐up, 520 pancreatic cancer cases were available for analysis. Results: Compared to never cigarette smokers, both former and current cigarette smokers had an increased pancreatic cancer risk (multivariable‐adjusted hazard rate ratio (HR) = 1.34; 95% confidence interval (CI) = 1.02–1.75 and HR = 1.82; 95% CI = 1.40–2.38, respectively). We observed an increased pancreatic cancer risk of 38% (95% CI = 1.01–1.87) with smoking ≥20 cigarettes per day compared to never cigarette smoking. The trend test was significant (P = 0.03), but no clear dose‐response relation was present. For duration of smoking, we observed an increased pancreatic cancer risk per increment of 10 years (multivariable‐adjusted HR = 1.15; 95% CI = 1.08–1.22), with a clear dose response effect observing a 2‐fold increased cancer risk comparing ≥40 years of smoking to never cigarette smoking. Quitting smoking gradually reduced the risk of pancreatic cancer (HR = 1.83, 1.41, and 1.42 for currents smokers, ex‐smokers quitted 0.1– Conclusion: Overall, our findings confirmed that cigarette smoking is an important risk factor for pancreatic cancer, while quitting smoking reduced risk. Therefore from a public health perspective, quitting smoking would benefit the burden on pancreatic cancer incidence and mortality. No association was observed between ETS and pancreatic cancer. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B140." @default.
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- W2334023746 date "2010-01-07" @default.
- W2334023746 modified "2023-09-27" @default.
- W2334023746 title "Abstract B140: Exposure and the risk of pancreatic cancer: Results of the Netherlands Cohort Study" @default.
- W2334023746 doi "https://doi.org/10.1158/1940-6207.prev-09-b140" @default.
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