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- W2334032054 abstract "Tuberculosis is the most widespread infectious respiratory disease with the largest incidence. To control the spread of tuberculosis, identifying rapid and accurate early diagnostic methods is of great importance. The polymerase chain reaction (PCR) is a simple, rapid, sensitive, and specific gene diagnostic technology, but there are still some problems in selecting appropriate diagnostic targets. Modern computational biology and bioinformatics provide powerful tools to screen new diagnostic targets for tuberculosis. In this article, we compared all genes of Mycobacterium tuberculosis H37Rv to all microbial genes that have been sequenced by genome-wide high-throughput scanning technology, and identified 12 genes that are only present in M. tuberculosis. Three of these genes, Rv1513, Rv1976, and Rv3738, can be used for early diagnostic screening. The specificity of using the three genes for diagnostic screening was validated on clinical tuberculosis specimens using the PCR method. We also performed PCR to investigate whether the three diagnostic genes could be detected in asthma, pneumonia, and lung cancer samples and the results were negative. These results demonstrate that the three genes can be used as targets for the early diagnosis of tuberculosis." @default.
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- W2334032054 date "2016-01-09" @default.
- W2334032054 modified "2023-10-11" @default.
- W2334032054 title "Identification And Validation Of Highly Specific And StableDiagnostic Targets In Mycobacterium tuberculosis" @default.
- W2334032054 hasPublicationYear "2016" @default.
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