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• W2334036609 endingPage "510" @default.
• W2334036609 startingPage "510" @default.
• W2334036609 abstract "The proliferative response of the neuroblastoma line NB69 to a 100 µT, 50 Hz magnetic field (MF) has been shown mediated by activation of the MAPK-ERK1/2 pathway. This work investigates the MF effect on the cell cycle of NB69, the participation of p38 and c-Jun N-terminal (JNK) kinases in the field-induced proliferative response and the potential involvement of reactive oxygen species (ROS) in the activation of the MAPK-ERK1/2 and -p38 signaling pathways. NB69 cultures were exposed to the 100 µT MF, either intermittently for 24, 42 or 63 h, or continuously for periods of 15 to 120 min, in the presence or absence of p38 or JNK inhibitors: SB203580 and SP600125, respectively. Antioxidant N-acetylcysteine (NAC) was used as ROS scavenger. Field exposure induced transient activation of p38, JNK and ERK1/2. The MF proliferative effect, which was mediated by changes in the cell cycle, was blocked by the p38 inhibitor, but not by the JNK inhibitor. NAC blocked the field effects on cell proliferation and p38 activation, but not those on ERK1/2 activation. The MF-induced proliferative effects are exerted through sequential upregulation of MAPK-p38 and -ERK1/2 activation, and they are likely mediated by a ROS-dependent activation of p38." @default.
• W2334036609 created "2016-06-24" @default.
• W2334036609 creator A5029680972 @default.
• W2334036609 creator A5060929083 @default.
• W2334036609 creator A5070108840 @default.
• W2334036609 creator A5076825444 @default.
• W2334036609 date "2016-04-06" @default.
• W2334036609 modified "2023-10-16" @default.
• W2334036609 title "Power Frequency Magnetic Fields Affect the p38 MAPK-Mediated Regulation of NB69 Cell Proliferation Implication of Free Radicals" @default.
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• W2334036609 doi "https://doi.org/10.3390/ijms17040510" @default.
• W2334036609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4848966" @default.
• W2334036609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27058530" @default.
• W2334036609 hasPublicationYear "2016" @default.

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