Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334048452> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2334048452 abstract "Introduction Langerhans cell histiocytosis (LCH) is characterised by a reactive clonal proliferation and accumulation of dendritic cells with a wide range of clinical presentations. Survival rate depend on single or multisystem disease. Objectives The aim of the study was to analyse the clinical, radiologic features and responses to treatment. Materials and methods We retrospectively reviewed the clinical data, histopathological, radiologic features, treatment modalities, and outcome of patients presenting with LCH. Results 9 patients were included with two brothers. There were 5 girls and 5 boys. Mean Age at diagnosis was 39 months. The main clinical feature was prolonged ferver (5 cases), and impaired general condition (3 cases). Skin involvement was present in 5 patients, otitis in 3 patients and 3 cases of lung injury with Spontaneous pneumothorax in one case. 3 different Tumour syndromes were observed at diagnosis. The most of patients present a multi-system disease. Radiologic finding showed 2 cases of bone involvement. The bone marrow involvement was present in 2 patients. Six patients received corticosteroid and vinblastine combination with the use of cyclosporine in 3 cases. One patient developed insipidus diabetes. Two patients dead. Conclusion Childhood Langherhans cell histiocytosis is a rare and poorly understood multi-system disease. Treatment decisions are difficult given the unpredictable course of the disease sometimes spontaneous, mainly for unifocal forms remissions. Patients with localised disease generally have a good prognosis and require minimal treatment. However, patients with lesions in ‘risk’ organs (liver, spleen, lung, bone marrow) have a worse overall prognosis regarding mortality and morbidity." @default.
- W2334048452 created "2016-06-24" @default.
- W2334048452 creator A5006259511 @default.
- W2334048452 creator A5008972150 @default.
- W2334048452 creator A5027900296 @default.
- W2334048452 creator A5037017657 @default.
- W2334048452 creator A5055369352 @default.
- W2334048452 creator A5065636465 @default.
- W2334048452 creator A5066353382 @default.
- W2334048452 creator A5071796913 @default.
- W2334048452 creator A5082765828 @default.
- W2334048452 date "2014-10-01" @default.
- W2334048452 modified "2023-09-24" @default.
- W2334048452 title "PO-0379 Different Aspect Of Childhood Langherhans Cell Histiocytosis : Experience From A Single Centre" @default.
- W2334048452 doi "https://doi.org/10.1136/archdischild-2014-307384.1025" @default.
- W2334048452 hasPublicationYear "2014" @default.
- W2334048452 type Work @default.
- W2334048452 sameAs 2334048452 @default.
- W2334048452 citedByCount "0" @default.
- W2334048452 crossrefType "journal-article" @default.
- W2334048452 hasAuthorship W2334048452A5006259511 @default.
- W2334048452 hasAuthorship W2334048452A5008972150 @default.
- W2334048452 hasAuthorship W2334048452A5027900296 @default.
- W2334048452 hasAuthorship W2334048452A5037017657 @default.
- W2334048452 hasAuthorship W2334048452A5055369352 @default.
- W2334048452 hasAuthorship W2334048452A5065636465 @default.
- W2334048452 hasAuthorship W2334048452A5066353382 @default.
- W2334048452 hasAuthorship W2334048452A5071796913 @default.
- W2334048452 hasAuthorship W2334048452A5082765828 @default.
- W2334048452 hasBestOaLocation W23340484521 @default.
- W2334048452 hasConcept C141071460 @default.
- W2334048452 hasConcept C142724271 @default.
- W2334048452 hasConcept C187212893 @default.
- W2334048452 hasConcept C2776439223 @default.
- W2334048452 hasConcept C2776958162 @default.
- W2334048452 hasConcept C2777484599 @default.
- W2334048452 hasConcept C2778329176 @default.
- W2334048452 hasConcept C2779134260 @default.
- W2334048452 hasConcept C2780007613 @default.
- W2334048452 hasConcept C2780174970 @default.
- W2334048452 hasConcept C71924100 @default.
- W2334048452 hasConceptScore W2334048452C141071460 @default.
- W2334048452 hasConceptScore W2334048452C142724271 @default.
- W2334048452 hasConceptScore W2334048452C187212893 @default.
- W2334048452 hasConceptScore W2334048452C2776439223 @default.
- W2334048452 hasConceptScore W2334048452C2776958162 @default.
- W2334048452 hasConceptScore W2334048452C2777484599 @default.
- W2334048452 hasConceptScore W2334048452C2778329176 @default.
- W2334048452 hasConceptScore W2334048452C2779134260 @default.
- W2334048452 hasConceptScore W2334048452C2780007613 @default.
- W2334048452 hasConceptScore W2334048452C2780174970 @default.
- W2334048452 hasConceptScore W2334048452C71924100 @default.
- W2334048452 hasLocation W23340484521 @default.
- W2334048452 hasLocation W23340484522 @default.
- W2334048452 hasOpenAccess W2334048452 @default.
- W2334048452 hasPrimaryLocation W23340484521 @default.
- W2334048452 hasRelatedWork W1856261719 @default.
- W2334048452 hasRelatedWork W2002185591 @default.
- W2334048452 hasRelatedWork W2012226885 @default.
- W2334048452 hasRelatedWork W2061796057 @default.
- W2334048452 hasRelatedWork W2077788071 @default.
- W2334048452 hasRelatedWork W2090855721 @default.
- W2334048452 hasRelatedWork W2187586393 @default.
- W2334048452 hasRelatedWork W2396066201 @default.
- W2334048452 hasRelatedWork W2401475804 @default.
- W2334048452 hasRelatedWork W2413229911 @default.
- W2334048452 hasRelatedWork W2438461740 @default.
- W2334048452 hasRelatedWork W2463978526 @default.
- W2334048452 hasRelatedWork W2464795807 @default.
- W2334048452 hasRelatedWork W2608524394 @default.
- W2334048452 hasRelatedWork W2895843062 @default.
- W2334048452 hasRelatedWork W3018452761 @default.
- W2334048452 hasRelatedWork W3084562101 @default.
- W2334048452 hasRelatedWork W3116199974 @default.
- W2334048452 hasRelatedWork W3206142449 @default.
- W2334048452 hasRelatedWork W3212136929 @default.
- W2334048452 isParatext "false" @default.
- W2334048452 isRetracted "false" @default.
- W2334048452 magId "2334048452" @default.
- W2334048452 workType "article" @default.