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- W2334078858 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCAlthough the number of new cases of Basal Cell Carcinoma (BCC) has increased rapidly each year in the last few decades, the molecular basis of its pathogenesis is not completely understood. Activation of Hedgehog (Hh) signaling pathway was shown to be a key factor driving the development of BCC. The Wnt/β-catenin signaling pathway was also shown to be activated in BCCs and to perhaps modulate the activity of Hh pathway. We previously identified a novel mechanism by which Wnt signaling regulates the transcriptional outcome of Hh signaling pathway. We demonstrated that CRD-BP, a direct target of the Wnt/β-catenin signaling, induces the expression and transcriptional activity of the Hh transcriptional activator GLI1. We hypothesized that Wnt-induced and CRD-BP-dependent regulation of GLI1 expression and activities is important to the development of BCC. In this study, the role of CRD-BP in the development of human BCC will be discussed.Citation Format: Felicite Kamdem Noubissi, Tae Won Kim, Tisha Kawahara, B. Jack Longley, Eric Berg, Mohammad Athar, Vladimir S. Spiegelman. Role of CRD-BP in the pathogenesis of human basal cell carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5444. doi:10.1158/1538-7445.AM2013-5444" @default.
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- W2334078858 date "2013-04-15" @default.
- W2334078858 modified "2023-09-27" @default.
- W2334078858 title "Abstract 5444: Role of CRD-BP in the pathogenesis of human basal cell carcinoma." @default.
- W2334078858 doi "https://doi.org/10.1158/1538-7445.am2013-5444" @default.
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