FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334100989> ?p ?o ?g. }

• W2334100989 endingPage "120" @default.
• W2334100989 startingPage "115" @default.
• W2334100989 abstract "FUS-induced BBB opening is a promising technique for noninvasive and local delivery of drugs into the brain. Here we propose the novel use of a neuronavigation system to guide the FUS-induced BBB opening procedure and investigate its feasibility in vivo in large animals.We developed an interface between the neuronavigator and FUS to allow guidance of the focal energy produced by the FUS transducer. The system was tested in 29 swine by more than 40 sonication procedures and evaluated by MR imaging. Gd-DTPA concentration was quantitated in vivo by MR imaging R1 relaxometry and compared with ICP-OES assay. Brain histology after FUS exposure was investigated using H&E and TUNEL staining.Neuronavigation could successfully guide the focal beam, with precision comparable to neurosurgical stereotactic procedures (2.3 ± 0.9 mm). A FUS pressure of 0.43 MPa resulted in consistent BBB opening. Neuronavigation-guided BBB opening increased Gd-DTPA deposition by up to 1.83 mmol/L (a 140% increase). MR relaxometry demonstrated high correlation with ICP-OES measurements (r(2) = 0.822), suggesting that Gd-DTPA deposition can be directly measured by imaging.Neuronavigation provides sufficient precision for guiding FUS to temporally and locally open the BBB. Gd-DTPA deposition in the brain can be quantified by MR relaxometry, providing a potential tool for the in vivo quantification of therapeutic agents in CNS disease treatment." @default.
• W2334100989 created "2016-06-24" @default.
• W2334100989 creator A5015998121 @default.
• W2334100989 creator A5016668277 @default.
• W2334100989 creator A5020797189 @default.
• W2334100989 creator A5022973219 @default.
• W2334100989 creator A5032447903 @default.
• W2334100989 creator A5040829611 @default.
• W2334100989 creator A5048680974 @default.
• W2334100989 creator A5052314950 @default.
• W2334100989 creator A5056482531 @default.
• W2334100989 creator A5073894030 @default.
• W2334100989 date "2012-06-21" @default.
• W2334100989 modified "2023-10-18" @default.
• W2334100989 title "Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine" @default.
• W2334100989 cites W1977845771 @default.
• W2334100989 cites W1978617007 @default.
• W2334100989 cites W1983771172 @default.
• W2334100989 cites W2003736464 @default.
• W2334100989 cites W2017733892 @default.
• W2334100989 cites W2021883922 @default.
• W2334100989 cites W2025191689 @default.
• W2334100989 cites W2027831237 @default.
• W2334100989 cites W2028267884 @default.
• W2334100989 cites W2034588968 @default.
• W2334100989 cites W2046342806 @default.
• W2334100989 cites W2058265539 @default.
• W2334100989 cites W2061287955 @default.
• W2334100989 cites W2066836726 @default.
• W2334100989 cites W2068597696 @default.
• W2334100989 cites W2071956340 @default.
• W2334100989 cites W2077435996 @default.
• W2334100989 cites W2084355055 @default.
• W2334100989 cites W2087666006 @default.
• W2334100989 cites W2094621092 @default.
• W2334100989 cites W2103225095 @default.
• W2334100989 cites W2115362657 @default.
• W2334100989 cites W2133343103 @default.
• W2334100989 cites W2135999437 @default.
• W2334100989 cites W2144352085 @default.
• W2334100989 doi "https://doi.org/10.3174/ajnr.a3150" @default.
• W2334100989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7966321" @default.
• W2334100989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22723060" @default.
• W2334100989 hasPublicationYear "2012" @default.
• W2334100989 type Work @default.
• W2334100989 sameAs 2334100989 @default.
• W2334100989 citedByCount "42" @default.
• W2334100989 countsByYear W23341009892013 @default.
• W2334100989 countsByYear W23341009892014 @default.
• W2334100989 countsByYear W23341009892015 @default.
• W2334100989 countsByYear W23341009892016 @default.
• W2334100989 countsByYear W23341009892018 @default.
• W2334100989 countsByYear W23341009892019 @default.
• W2334100989 countsByYear W23341009892020 @default.
• W2334100989 countsByYear W23341009892021 @default.
• W2334100989 countsByYear W23341009892022 @default.
• W2334100989 countsByYear W23341009892023 @default.
• W2334100989 crossrefType "journal-article" @default.
• W2334100989 hasAuthorship W2334100989A5015998121 @default.
• W2334100989 hasAuthorship W2334100989A5016668277 @default.
• W2334100989 hasAuthorship W2334100989A5020797189 @default.
• W2334100989 hasAuthorship W2334100989A5022973219 @default.
• W2334100989 hasAuthorship W2334100989A5032447903 @default.
• W2334100989 hasAuthorship W2334100989A5040829611 @default.
• W2334100989 hasAuthorship W2334100989A5048680974 @default.
• W2334100989 hasAuthorship W2334100989A5052314950 @default.
• W2334100989 hasAuthorship W2334100989A5056482531 @default.
• W2334100989 hasAuthorship W2334100989A5073894030 @default.
• W2334100989 hasBestOaLocation W23341009891 @default.
• W2334100989 hasConcept C126838900 @default.
• W2334100989 hasConcept C136229726 @default.
• W2334100989 hasConcept C142724271 @default.
• W2334100989 hasConcept C143409427 @default.
• W2334100989 hasConcept C143753070 @default.
• W2334100989 hasConcept C150903083 @default.
• W2334100989 hasConcept C207001950 @default.
• W2334100989 hasConcept C2778195096 @default.
• W2334100989 hasConcept C2989005 @default.
• W2334100989 hasConcept C71924100 @default.
• W2334100989 hasConcept C73286259 @default.
• W2334100989 hasConcept C83042744 @default.
• W2334100989 hasConcept C86803240 @default.
• W2334100989 hasConceptScore W2334100989C126838900 @default.
• W2334100989 hasConceptScore W2334100989C136229726 @default.
• W2334100989 hasConceptScore W2334100989C142724271 @default.
• W2334100989 hasConceptScore W2334100989C143409427 @default.
• W2334100989 hasConceptScore W2334100989C143753070 @default.
• W2334100989 hasConceptScore W2334100989C150903083 @default.
• W2334100989 hasConceptScore W2334100989C207001950 @default.
• W2334100989 hasConceptScore W2334100989C2778195096 @default.
• W2334100989 hasConceptScore W2334100989C2989005 @default.
• W2334100989 hasConceptScore W2334100989C71924100 @default.
• W2334100989 hasConceptScore W2334100989C73286259 @default.
• W2334100989 hasConceptScore W2334100989C83042744 @default.
• W2334100989 hasConceptScore W2334100989C86803240 @default.
• W2334100989 hasIssue "1" @default.
• W2334100989 hasLocation W23341009891 @default.
• W2334100989 hasLocation W23341009892 @default.

• next