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- W2334129369 abstract "The absorption, distribution, metabolism and excretion of cefixime, an orally active cephem antibiotic, were studied in rat given the 14C-labeled drug intravenously or orally in solution. After intravenous dosing, serum concentrations of the unchanged cefixime declined two-exponentially with respective half-lives of 0.31 and 1.33 hr. The total serum clearance and the volume of distribution at steady state were 1.68 ml/min/kg and 176 ml/kg, respectively. After oral dosing, the maximal serum concentrations of the unchanged cefixime were reached at 1 hr and declined with an apparent half-life of 2.46 hr. Oral bioavailability was 23 ?? 27%. Most of the serum radioactivity was from the unchanged cefixime regardless of dosing route. Radioactivity taken into the systemic circulation was rapidly disributed in the various tissues, and was high in the kidneys, urinary bladder, blood and liver. After intravenous dosing, excretion of radioactivity was 82 % of the dose in the urine and 22 % in the feces. Biliary recovery of radioactivity was 35 %. After oral dosing, excretion of radioactivity was 20 % in the urine and 85 % in the feces. Most of the radioactivity in the urine and bile after dosing by either route was in the form of the unchanged cefixime." @default.
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- W2334129369 date "1987-01-01" @default.
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- W2334129369 title "Absorption, distribution, excretion and metabolism of cefixime in rats." @default.
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- W2334129369 doi "https://doi.org/10.2133/dmpk.2.637" @default.
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