FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2334129675> ?p ?o ?g. }

• W2334129675 endingPage "2899" @default.
• W2334129675 startingPage "2889" @default.
• W2334129675 abstract "Cyclin-dependent kinase 6(cdk6) is present in randomly proliferating cultures of 3T3 cells but has little detectable enzymatic activity. Significant activity is detected only during a short period in early G1 phase. To examine the possible functions of cdk6 in 3T3 cells, lines stably over-expressing cdk6 were constructed and compared to normal 3T3 cells or cell lines with reduced cdk6 levels due to expression of a dominant-negative form of the protein. Over-expression of cdk6 in cells, which led to high levels of activity even in proliferating cultures, had dramatic effects. Cell lines stably over-expressing wild-type cdk6 had a markedly reduced growth rate compared to parental 3T3 cells or lines expressing a dominant-negative form of cdk6. They also over-produced the p53 and p130 proteins and had increased sensitivity to UV-irradiation. Irradiation resulted in accumulation of the Bax protein and rapid cell death. Levels of p53 and p130 proteins were down-regulated and the growth rate of the cells was increased by introduction of the dominant-negative form of cdk6 into cells over-expressing cdk6, indicating that cdk6 is involved in the overproduction of p53 and p130. The results suggest that cdk6, through regulation of growth-suppressing molecules, may play a role in halting cellular growth when proliferation is inappropriate." @default.
• W2334129675 created "2016-06-24" @default.
• W2334129675 creator A5023276521 @default.
• W2334129675 creator A5023960478 @default.
• W2334129675 creator A5064951922 @default.
• W2334129675 date "2001-05-24" @default.
• W2334129675 modified "2023-10-11" @default.
• W2334129675 title "Accumulation of high levels of the p53 and p130 growth-suppressing proteins in cell lines stably over-expressing cyclin-dependent kinase 6 (cdk6)" @default.
• W2334129675 cites W1265915885 @default.
• W2334129675 cites W133264087 @default.
• W2334129675 cites W14542710 @default.
• W2334129675 cites W1479945915 @default.
• W2334129675 cites W1480475289 @default.
• W2334129675 cites W1486295148 @default.
• W2334129675 cites W1520222296 @default.
• W2334129675 cites W1564355448 @default.
• W2334129675 cites W1594985705 @default.
• W2334129675 cites W1615014609 @default.
• W2334129675 cites W1932315029 @default.
• W2334129675 cites W1988756673 @default.
• W2334129675 cites W1991494214 @default.
• W2334129675 cites W1994539742 @default.
• W2334129675 cites W1996180957 @default.
• W2334129675 cites W1997945271 @default.
• W2334129675 cites W1999330214 @default.
• W2334129675 cites W2002114666 @default.
• W2334129675 cites W2010298858 @default.
• W2334129675 cites W2010493387 @default.
• W2334129675 cites W2012480580 @default.
• W2334129675 cites W2013683475 @default.
• W2334129675 cites W2014944254 @default.
• W2334129675 cites W2015066175 @default.
• W2334129675 cites W2015519364 @default.
• W2334129675 cites W201567762 @default.
• W2334129675 cites W2022782470 @default.
• W2334129675 cites W2026084872 @default.
• W2334129675 cites W2027376766 @default.
• W2334129675 cites W2029080338 @default.
• W2334129675 cites W2035320598 @default.
• W2334129675 cites W2035882662 @default.
• W2334129675 cites W2036259493 @default.
• W2334129675 cites W2038407368 @default.
• W2334129675 cites W2042877528 @default.
• W2334129675 cites W2045086385 @default.
• W2334129675 cites W2046854154 @default.
• W2334129675 cites W2056716049 @default.
• W2334129675 cites W2056718772 @default.
• W2334129675 cites W2058582870 @default.
• W2334129675 cites W2063324806 @default.
• W2334129675 cites W2078596153 @default.
• W2334129675 cites W2087551298 @default.
• W2334129675 cites W2087732988 @default.
• W2334129675 cites W2092433246 @default.
• W2334129675 cites W2095241070 @default.
• W2334129675 cites W2095690095 @default.
• W2334129675 cites W2098795903 @default.
• W2334129675 cites W2102380059 @default.
• W2334129675 cites W2106410559 @default.
• W2334129675 cites W2112555367 @default.
• W2334129675 cites W2120194106 @default.
• W2334129675 cites W2125072003 @default.
• W2334129675 cites W2126094070 @default.
• W2334129675 cites W2134979684 @default.
• W2334129675 cites W2150710841 @default.
• W2334129675 cites W2156650182 @default.
• W2334129675 cites W2162429172 @default.
• W2334129675 cites W2168171864 @default.
• W2334129675 cites W2169344668 @default.
• W2334129675 cites W2169413646 @default.
• W2334129675 cites W2172249054 @default.
• W2334129675 cites W2333562168 @default.
• W2334129675 cites W2409576724 @default.
• W2334129675 cites W4243251494 @default.
• W2334129675 cites W4246593990 @default.
• W2334129675 cites W4254707873 @default.
• W2334129675 cites W4321429134 @default.
• W2334129675 cites W93514313 @default.
• W2334129675 doi "https://doi.org/10.1038/sj.onc.1204396" @default.
• W2334129675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11420701" @default.
• W2334129675 hasPublicationYear "2001" @default.
• W2334129675 type Work @default.
• W2334129675 sameAs 2334129675 @default.
• W2334129675 citedByCount "21" @default.
• W2334129675 countsByYear W23341296752014 @default.
• W2334129675 countsByYear W23341296752015 @default.
• W2334129675 countsByYear W23341296752016 @default.
• W2334129675 countsByYear W23341296752018 @default.
• W2334129675 countsByYear W23341296752019 @default.
• W2334129675 countsByYear W23341296752020 @default.
• W2334129675 countsByYear W23341296752023 @default.
• W2334129675 crossrefType "journal-article" @default.
• W2334129675 hasAuthorship W2334129675A5023276521 @default.
• W2334129675 hasAuthorship W2334129675A5023960478 @default.
• W2334129675 hasAuthorship W2334129675A5064951922 @default.
• W2334129675 hasBestOaLocation W23341296751 @default.
• W2334129675 hasConcept C124320809 @default.
• W2334129675 hasConcept C1491633281 @default.
• W2334129675 hasConcept C153911025 @default.

• next